Alpha,Alpha-二氯苯丙酮合成路线 （共 20 条）
反应条件
1: N-chlorosuccinimide / toluene
2: aq. sulfuric acid / tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Barluenga, Jose; Tomas, Miguel; Lopez-Ortiz, J. Francisco; Gotor, Vicente
Synthesis, 1984 , # 11 p. 935 - 936
反应条件
1: N-chlorosuccinimide / toluene
2: aq. sulfuric acid / tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Barluenga, Jose; Tomas, Miguel; Lopez-Ortiz, J. Francisco; Gotor, Vicente
Synthesis, 1984 , # 11 p. 935 - 936
反应条件
1: 83 percent / N-chlorosuccinimide / toluene / 3 h / 50 °C
2: aq. sulfuric acid / tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Barluenga, Jose; Tomas, Miguel; Lopez-Ortiz, J. Francisco; Gotor, Vicente
Synthesis, 1984 , # 11 p. 935 - 936
反应条件
1: 89 percent / N-chlorosuccinimide / toluene / 3 h / 50 °C
2: aq. sulfuric acid / tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Barluenga, Jose; Tomas, Miguel; Lopez-Ortiz, J. Francisco; Gotor, Vicente
Synthesis, 1984 , # 11 p. 935 - 936
反应条件
sulfuric acid in tetrahydrofuran
4 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Barluenga, Jose; Tomas, Miguel; Lopez-Ortiz, J. Francisco; Gotor, Vicente
Synthesis, 1984 , # 11 p. 935 - 936
反应条件
sulfuric acid in tetrahydrofuran
4 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Barluenga, Jose; Tomas, Miguel; Lopez-Ortiz, J. Francisco; Gotor, Vicente
Synthesis, 1984 , # 11 p. 935 - 936
反应条件
1: 45 percent / m-chloroperbenzoic acid / CH2Cl2 / 18 h / Heating
2: AgBF4 / diethyl ether / 1) -20 deg C, 5 min, 2) 0 deg C, 1 h
View Scheme
参考文献
Griesbaum, Karl; Keul, Helmut; Kibar, Riza; Pfeffer, Bernd; Spraul, Manfred
Chemische Berichte, 1981 , vol. 114, # 5 p. 1858 - 1870
反应条件
silver tetrafluoroborate in diethyl ether
1) -20 deg C, 5 min, 2) 0 deg C, 1 h; Yield given. Yields of byproduct given;
参考文献
Griesbaum, Karl; Keul, Helmut; Kibar, Riza; Pfeffer, Bernd; Spraul, Manfred
Chemische Berichte, 1981 , vol. 114, # 5 p. 1858 - 1870
反应条件
hydrogenchloride; diethyl ether
参考文献
De Kimpe,N. et al.
Synthetic Communications, 1978 , vol. 8, p. 75 - 85
反应条件
lithium diisopropyl amide
1.) THF, Et2O, -10 degC, 0.5 h, 2.) THF, Et2O, DMF, 25 degC, 24 h; Yield given. Multistep reaction;
参考文献
Posner, Gary H.; Mallamo, John P.; Black, Alison Y.
Tetrahedron, 1981 , vol. 37, # 23 p. 3921 - 3926
