4-(4-甲氧基苯基)-2-甲基-4-氧代丁酸合成路线 （共 7 条）
反应条件
AlCl3, aluminium chloride in nitrobenzene T=0 - 20°C;
参考文献
Deng, Fei; Xu, Jun; Zhao, Min; Liu, Hong-Ying; Ye, Yang; Zhang, Jin-Sheng
Helvetica Chimica Acta, 2011 , vol. 94, # 7 p. 1326 - 1334
反应条件
1: α-4-methoxyphenyl-α-(4-morpholino)acetonitrile With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methacrylic acid methyl ester in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Pawar; Waghmare; Lokhande
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 11 p. 2549 - 2551
反应条件
sodium hydroxide in ethanol 0.5 h;
参考文献
Journal of the American Chemical Society, , vol. 125, # 44 p. 13368 - 13369
反应条件
1.1: LDA / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: hexane; tetrahydrofuran / -78 - 20 °C 2.1: 0.877 g / aq. NaOH / ethanol / 0.5 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 3 p. 925 - 934
反应条件
aluminium trichloride in nitromethane Ambient temperature; Yields of byproduct given;
参考文献
Gaare, Kristin; Akporiaye, Duncan; Holm, Kjetil; Skattebol, Lars
Acta Chemica Scandinavica, 1997 , vol. 51, # 12 p. 1229 - 1233
反应条件
hydrogenchloride in 1,4-dioxane Heating;
参考文献
Gazzetta Chimica Italiana, , vol. 97, p. 654 - 664
反应条件
1: 50percent hydrobromic acid / H2O / 16 h / Heating
2: p-toluenesulphonic acid / 5 h / Heating
3: 1) Na / 1) methanol, 10 min, 2) DMSO, 100 deg C, 8 h
View Scheme
参考文献
Kuchar, Miroslav; Brunova, Bohumila; Grimova, Jaroslava; Rejholec, Vaclav; Cepelak, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 11 p. 2617 - 2625
