3-羟基-5-甲氧基苯甲醛合成路线 （共 13 条）
反应条件
formaldehyd; ethyl mercaptan sodium salt in N,N-dimethyl-formamide
T=145°C; 1 h;
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter R.
Patent: US2013/281399 A1, 2013 ;
Location in patent: Paragraph 0791; 0797 ;
反应条件
1: 3,5-dihydroxybenzaldehyde With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 0.5 h;
2: methyl iodide in N,N-dimethyl-formamide
16 h;
参考文献
CURIS, INC.
Patent: WO2008/57497 A2, 2008 ;
Location in patent: Page/Page column 359-360 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=0°C; Methylation;
参考文献
Ortho-McNeil Pharmaceutical, Inc.
Patent: EP906091 B1, 2006 ;
Location in patent: Page/Page column 21 ;
反应条件
1: With lithium tri-t-butoxyaluminum hydride in tetrahydrofuran
T=20°C; 0.25 h; Inert atmosphere;
2: With zirconocene dichloride in tetrahydrofuran
T=20°C; 0.0333333 h; Inert atmosphere;
参考文献
Zhao, Yigang; Snieckus, Victor
Organic Letters, 2014 , vol. 16, # 2 p. 390 - 393
反应条件
triphenylphosphine in tetrahydrofuran; methanol; Petroleum ether
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US5891909 A1, 1999 ;
US 5891909 A
反应条件
hydrogenchloride; water in acetone
T=25°C; 0.5 h;
参考文献
SCHERING AKTINGESELLSCHAFT
Patent: WO2006/63805 A1, 2006 ;
Location in patent: Page/Page column 72-73 ;
WO 2006/063805 A1
反应条件
Pd-BaSO4; xylene
T=160°C; Hydrogenation;
参考文献
Spaeth; Kromp
Chemische Berichte, 1941 , vol. 74, p. 1424,1428
反应条件
Pd-BaSO4; toluene
T=110°C; Hydrogenation.und Verseifung des entstandenen 3-Methoxy-5-carbomethoxyoxy-benzaldehyds mit waessrig-alkoholischer Natronlauge in Wasserstoff-Atmosphaere;
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1927 , vol. <2> 116, p. 323
反应条件
2: thionyl chloride
3: xylene; palladium/barium sulfate / 160 °C / Hydrogenation
View Scheme
参考文献
Spaeth; Kromp
Chemische Berichte, 1941 , vol. 74, p. 1424,1428
反应条件
1: thionyl chloride
2: xylene; palladium/barium sulfate / 160 °C / Hydrogenation
View Scheme
参考文献
Spaeth; Kromp
Chemische Berichte, 1941 , vol. 74, p. 1424,1428
