6-甲氧基-2-苯基-4-喹诺酮合成路线 （共 9 条）
反应条件
in diphenylether
T=250°C; 0.166667 h; Inert atmosphereMicrowave irradiation;
参考文献
Romek, Alexandra; Opatz, Till
European Journal of Organic Chemistry, 2010 , # 30 p. 5841 - 5849
反应条件
sodium hydroxide in ethanol
6 h; Heating;
参考文献
Zhao, Yue-Ling; Chen, Yeh-Long; Chang, Feng-Shuo; Tzeng, Cherng-Chyi
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 792 - 797
反应条件
1: AcOH / ethanol / 24 h / 50 °C
2: diphenyl ether / 0.17 h / 240 - 250 °C
View Scheme
参考文献
Kuo; Lee; Juang; Lin; Wu; Chang; Lednicer; Paull; Hamel
Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1146 - 1156
反应条件
1: AcOH / ethanol / 24 h / 50 °C
2: diphenyl ether / 0.17 h / 240 - 250 °C
View Scheme
参考文献
Kuo; Lee; Juang; Lin; Wu; Chang; Lednicer; Paull; Hamel
Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1146 - 1156
反应条件
1: potassium carbonate; N-methyl-2-(methylamino)ethylamine / copper(l) iodide / toluene / 170 °C
2: sodium hydroxide / 1,4-dioxane / 110 °C
View Scheme
参考文献
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; UNIVERSITY PAUL CEZANNE MARSEILLE III/AIX; HIGGINS, Jonathan; CUNY, Gregory D.; GLICKSMAN, Marcie; PATNAIK, Debasis; ROBIN, Maxime; STEIN, Ross L.; XIAN, Jun
Patent: WO2011/127406 A2, 2011 ;
WO 2011/127406 A2
反应条件
1: potassium carbonate; N-methyl-2-(methylamino)ethylamine / copper(l) iodide / toluene / 170 °C
2: sodium hydroxide / 1,4-dioxane / 110 °C
View Scheme
参考文献
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; UNIVERSITY PAUL CEZANNE MARSEILLE III/AIX; HIGGINS, Jonathan; CUNY, Gregory D.; GLICKSMAN, Marcie; PATNAIK, Debasis; ROBIN, Maxime; STEIN, Ross L.; XIAN, Jun
Patent: WO2011/127406 A2, 2011 ;
WO 2011/127406 A2
反应条件
1: 82 percent / diphenyl ether / 1 h / 230 - 250 °C
2: 85 percent / NaOH / ethanol / 6 h / Heating
View Scheme
参考文献
Zhao, Yue-Ling; Chen, Yeh-Long; Chang, Feng-Shuo; Tzeng, Cherng-Chyi
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 792 - 797
反应条件
1: 78 percent / K2CO3 / dimethylformamide / 3 h / 140 °C
2: 82 percent / diphenyl ether / 1 h / 230 - 250 °C
3: 85 percent / NaOH / ethanol / 6 h / Heating
View Scheme
参考文献
Zhao, Yue-Ling; Chen, Yeh-Long; Chang, Feng-Shuo; Tzeng, Cherng-Chyi
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 792 - 797
反应条件
trichlorophosphate
Heating;
参考文献
Zhao, Yue-Ling; Chen, Yeh-Long; Chang, Feng-Shuo; Tzeng, Cherng-Chyi
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 8 p. 792 - 797
