6-甲氧基-1,2,3,4-四氢异喹啉盐酸盐合成路线 （共 12 条）
反应条件
hydrogenchloride in tert-butyl methyl ether; isopropyl alcohol T=20°C; 22 h; Inert atmosphere;
参考文献
Zhong, H. Marion; Villani, Frank J.; Marzouq, Ramzy
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 463 - 465
反应条件
hydrogenchloride in water 1.33333 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2003/99786 A2, 2003 ;
Location in patent: Page 35 ;
反应条件
hydrogenchloride in water; ethyl acetate T=100°C; Pictet-Spengler reaction; 1 h;
参考文献
EP1676844 A1, ;
Page/Page column 13 ;
参考文献
SmithKline and French Laboratories, Ltd.
Patent: US4812573 A1, 1989 ;
反应条件
1: ammonium acetate; acetic acid / 12 h / 100 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C 3: hydrogenchloride / water / 1 h / 60 °C 4: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3414 - 3418
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C 2: hydrogenchloride / water / 1 h / 60 °C 3: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3414 - 3418
反应条件
hydrogenchloride; sodium tetrahydroborate
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 501 - 526
反应条件
1: 19 percent / POCl3 2: 1.) NaBH4, 2.) HCl View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 501 - 526
反应条件
sodium hydrogencarbonate in water T=20°C; 0.5 h;
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
反应条件
1.1: hydrogen bromide; water / 5 h / |Reflux 2.1: triethylamine / tetrahydrofuran; water 3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C 3.2: 1 h 4.1: hydrogenchloride / water; ethanol / 6 h / 20 °C View Scheme
参考文献
Yang, Su Hui; Song, Chin-Hee; Van, Hue Thi My; Park, Eunsook; Khadka, Daulat Bikram; Gong, Eun-Yeung; Lee, Keesook; Cho, Won-Jea
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3414 - 3418
