2,4,6-三异丙基苯甲酰氯合成路线 （共 15 条）
参考文献
Journal of the American Chemical Society, , vol. 62, p. 2962
反应条件
1: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 30 min, 2.) 15 min 2: thionyl chloride / 16 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 11 p. 2363 - 2373
反应条件
1: tetrachloromethane; iron; bromine / 0 °C / Lichtausschluss 2: magnesium; diethyl ether / Behandeln der Reaktionsloesung mit festem Kohlendioxid 3: thionyl chloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 62, p. 2962
反应条件
1: NaH / 40 h / Heating 2: 1.) sec-BuLi, TMEDA / 1.) THF, -98 deg C, 2.) a) -98 deg C, b) from -98 deg C to RT 3: 90 percent / NaH / tetrahydrofuran / 19 h / Ambient temperature View Scheme
参考文献
Beak, Peter; Becker, Peter D.
Journal of Organic Chemistry, 1982 , vol. 47, # 20 p. 3855 - 3861
反应条件
2: dibutyl ether View Scheme
参考文献
Fuson; Bottorff; Speck
Journal of the American Chemical Society, 1942 , vol. 64, p. 1450
Journal of the American Chemical Society, 1944 , vol. 66, p. 2135
反应条件
in diethyl ether; toluene T=0°C; 24 h; Inert atmosphere;
参考文献
Molecules, , vol. 17, # 6 p. 6415 - 6423
反应条件
1: ethanol With sodium hydride in tetrahydrofuran; mineral oil 0.166667 h; Inert atmosphere; 2: TIBCl in tetrahydrofuran; mineral oil T=80°C; 16 h; Inert atmosphereSealed tube;
参考文献
Robinson, Anna; Aggarwal, Varinder K.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1795 - 1801
反应条件
1: 98 percent / LAH 2: 97 percent / PBr3 / diethyl ether 3: dimethylsulfoxide 4: aq. H2SO4 5: (COCl)2 6: 80 percent / TEA / tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 26 p. 5031 - 5034
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere 1.2: 18.08 h / 90 °C / Inert atmosphere 2.1: sec.-butyllithium; (-)-sparteine / diethyl ether; hexane; cyclohexane / 5 h / -78 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere; Reflux View Scheme
参考文献
Larouche-Gauthier, Robin; Fletcher, Catherine J.; Couto, Irantzu; Aggarwal, Varinder K.
Chemical Communications, 2011 , vol. 47, # 47 p. 12592 - 12594
反应条件
1: 98 percent / LAH 2: 97 percent / PBr3 / diethyl ether View Scheme
参考文献
Lee; Roark; Picard; Sliskovic; Roth; Stanfield; Hamelehle; Bousley; Krause
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 3 p. 289 - 294
