6-氧代环己烯-1-羧酸乙酯合成路线 （共 14 条）
反应条件
2: 97 percent / 50percent aq. AcOH / 30 h / Ambient temperature
View Scheme
参考文献
Kato, Michiharu; Kamat, Vijayendra P.; Yoshikoshi, Akira
Synthesis, 1988 , # 9 p. 699 - 701
反应条件
benzeneselenenyl chloride; dihydrogen peroxide; sodium hydride
1) THF, RT, 2) THF, RT; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Mittra, Asmita; Yamashita, Masayuki; Kawasaki, Ikuo; Murai, Hiromichi; Yoshioka, Tomomichi; Ohta, Shunsaku
Synlett, 1997 , vol. 1997, # 8 p. 909 - 910
参考文献
Balasubrahmanyam; Sivarajan
Indian Journal of Chemistry, 1969 , vol. 7, p. 876,879
反应条件
1: methyllithium With thien-2-yl(cyano)copper lithium in tetrahydrofuran; diethyl ether
T=-78°C; 0.166667 h;
2: ethyl 6-oxocyclohex-1-ene-1-carboxylate in tetrahydrofuran; diethyl ether
T=-78 - 20°C; 1.08333 h;
3: With ammonia; water; ammonium chloride in tetrahydrofuran; diethyl ether
参考文献
NPS PHARMACEUTICALS, INC.
Patent: WO2006/66070 A2, 2006 ;
Location in patent: Page/Page column 34 ;
