1: 2-methylpropanoic acid methyl ester With LiN(Cy)2 in toluene T=20°C; 0.166667 h; Inert atmosphere; 2: 1-chloro-4-bromobenzene With [P(t-Bu)3Pd(μ-Br)]2 in toluene T=20°C; 4 h; Inert atmosphere;

1: 4-chlorophenylacetic acid methyl ester With sodium hydride in tetrahydrofuran T=-10 - 0°C; Inert atmosphere; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; Inert atmosphere;

5-chloro-2-hydroxy-benzoic acid; boric acid; tris(4-methylphenyl)-phosphine; palladium diacetate P=31028.9 Torr; 48 h; Heating;