1-(甲氧基甲氧基)-3-甲基苯合成路线 （共 8 条）
反应条件
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium tert-butylate / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: hydrogenchloride / methanol; water / Reflux View Scheme
参考文献
Blangetti, Marco; Fleming, Patricia; O'Shea, Donal F.
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2870 - 2877
反应条件
1: 1.) tert-butyllithium / 1.) ether, hexane, -20 deg C, 1 h, 2.) 1 h 2: 1.) LDA / 1.) hexane, THF, 15 min, 2.) -78 deg C, 3 h 3: 91 percent / CH3CO2H / 6 h / Heating View Scheme
参考文献
Harvey; Cortez; Ananthanarayan; Schmolka
Journal of Organic Chemistry, 1988 , vol. 53, # 17 p. 3936 - 3943
反应条件
1.1: n-butyllithium / hexane; diethyl ether / 3 h / 0 - 20 °C / |Inert atmosphere 1.2: 0.17 h / 0 °C / |Inert atmosphere 1.3: |Inert atmosphere 2.1: montmorillonite K-10 / benzene / 24 h / |Reflux View Scheme
参考文献
Mori, Keiji; Ichikawa, Yuki; Kobayashi, Manato; Shibata, Yukihiro; Yamanaka, Masahiro; Akiyama, Takahiko
Journal of the American Chemical Society, 2013 , vol. 135, # 10 p. 3964 - 3970
反应条件
1: BuLi; I2 / diethyl ether 2: TMSCl; NaI / acetonitrile View Scheme
参考文献
Morice, Christophe; Domostoj, Mathias; Briner, Karin; Mann, Andre; Suffert, Jean; Wermuth, Camille-Georges
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6499 - 6502
反应条件
Yield given. Multistep reaction;
参考文献
Ronald, Robert C.; Gewali, Mohan B.; Ronald, Bruce P.
Journal of Organic Chemistry, 1980 , vol. 45, # 11 p. 2224 - 2229
反应条件
1: 3-methyl-phenol With sodium hydride in N,N-dimethyl-formamide
T=0°C; 1 h;
2: chloromethyl methyl ether
参考文献
Bristol-Myers Squibb Pharma Company
Patent: US6362180 B1, 2002 ;
Location in patent: Example 5001 ;
US 6362180 B1
反应条件
ZrO(OTf)2
T=20°C; 0.166667 h; neat (no solvent); chemoselective reaction;
参考文献
Moghadam, Majid; Tangestaninejad, Shahram; Mirkhani, Valiollah; Mohammadpoor-Baltork, Iraj; Khajehzadeh, Mostafa
Monatshefte fur Chemie, 2010 , vol. 141, # 6 p. 641 - 647
参考文献
Hoering; Baum
Patent: DE209608 ;
