1-(3,4-二氯苯基)哌嗪合成路线 （共 7 条）
反应条件
potassium carbonate in Petroleum ether; butan-1-ol
参考文献
A. H. Robins Company, Incorporated
Patent: US5086055 A1, 1992 ;
反应条件
1: With pyridine; potassium iodide T=100°C; 111 h; 2: With potassium tert-butylate in ethylene glycol dimethyl ether 3 h; Heating;
参考文献
Synthesis, , # 19 art. no. C08305SS, p. 3456 - 3462
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 15 p. 4393 - 4396
反应条件
1: ethanol / 24 h / Ambient temperature 2: methanol / 12 h / Ambient temperature View Scheme
参考文献
Bosc; Jarry; Carpy; Panconi; Descas
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 437 - 442
反应条件
1: triethylamine / toluene / Heating
2: H2 / Raney Ni / ethanol / 2327.2 Torr / Ambient temperature
View Scheme
参考文献
Saxena, Anil K.; Arunamurthy, V.; Patnaik, G. K.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 10 p. 873 - 878
反应条件
acetic acid in ethanol
24 h;
参考文献
Murti; Bhandari; Ram; Prabhakar; Saxena; Jain; Gulati; Srimal; Dhawan; Nityanand; Anand
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 11 p. 934 - 942
