1: piperazine With 2-chlorotrityl resin; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane T=20°C; 4 h; 3: With trifluoroacetic acid in dichloromethane
1: With lithium diisopropyl amide in tetrahydrofuran; hexane T=0°C; 0.25 h; Inert atmosphere; 2: With oxygen in tetrahydrofuran; hexane T=20°C; 1 h; 3: With water in tetrahydrofuran; hexane
