1-Boc-哌嗪合成路线

参考文献

GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WELLENZOHN, Bernd
Patent: US2013/143870 A1, 2013 ;
Location in patent: Paragraph 0371; 0372; 0373 ;

501-53-1氯甲酸苄酯+

57260-71-61-Boc-哌嗪

121370-60-31-苄基 4-叔丁基哌嗪-1,4-二羧酸

参考文献

Loewik, Dennis W. P. M.; Lowe, Christopher R.
European Journal of Organic Chemistry, 2001 , # 15 p. 2825 - 2840

57260-71-61-Boc-哌嗪

121370-60-31-苄基 4-叔丁基哌嗪-1,4-二羧酸

参考文献

Merck and Co., Inc.
Patent: US5057517 A1, 1991 ;

29232-39-12,3-二溴-5-甲基吡啶+

57260-71-61-Boc-哌嗪

1187386-02-22-(4-BOC-哌嗪o)-3-溴-5-甲基吡啶

参考文献

Hikawa, Hidemasa; Yokoyama, Yuusaku
Tetrahedron, 2010 , vol. 66, # 49 p. 9552 - 9559

87-42-36-氯嘌呤+

57260-71-61-Boc-哌嗪

121370-56-74-(9H-嘌呤)-哌嗪-1-羧酸叔丁酯

参考文献

Millennium Pharmaceuticals, Inc.
Patent: US2003/153556 A1, 2003 ;
US 20030153556 A1

3764-01-02,4,6-三氯嘧啶+

57260-71-61-Boc-哌嗪

1155306-28-74-(2,6-二氯嘧啶-4-基)哌嗪-1-羧酸叔丁酯

参考文献

F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.
Patent: WO2009/66084 A1, 2009 ;
Location in patent: Page/Page column 65-66 ;
WO 2009/066084 A1

3764-01-02,4,6-三氯嘧啶+

57260-71-61-Boc-哌嗪

1155306-28-74-(2,6-二氯嘧啶-4-基)哌嗪-1-羧酸叔丁酯+

1197341-88-0

参考文献

Ho, Koc-Kan; Beasley, James R.; Belanger, Laura; Black, Darcey; Chan, Jui-Hsiang; Dunn, David; Hu, Bing; Klon, Anthony; Kultgen, Steven G.; Ohlmeyer, Michael; Parlato, Susan M.; Ray, Peter C.; Pham, Quynhchi; Rong, Yajing; Roughton, Andrew L.; Walker, Tiffany L.; Wright, Jane; Xu, Kai; Xu, Yan; Zhang, Limei; Webb, Maria
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6027 - 6031

128071-98-74-溴-2-氟吡啶+

57260-71-61-Boc-哌嗪

1197294-80-64-(4-溴吡啶-2-基)哌嗪-1-羧酸叔丁酯

参考文献

Almirall, S.A.; Vidal Juan, Bernat; Forns Berenguel, Maria Pilar; Castillo Mcquade, Marcos; Erra Sola, Montserrat; Mir Cepeda, Marta
Patent: EP2441755 A1, 2012 ;
Location in patent: Paragraph 0176 ;

611-35-84-氯喹啉+

57260-71-61-Boc-哌嗪

118306-89-1

参考文献

Yeung, Kap-Sun; Farkas, Michelle E.; Kadow, John F.; Meanwell, Nicholas A.; Taylor, Malcolm; Johnston, David; Coulter, Thomas Stephen; Wright, J. J. Kim
Patent: US2005/261296 A1, 2005 ;

57260-71-61-Boc-哌嗪+

1489-69-6环丙甲醛

373608-50-5

参考文献

Dorwald, Florencio Zaragoza; Andersen, Knud Erik; Sorensen, Jan Lindy
Patent: US2004/19039 A1, 2004 ;
Location in patent: Page/Page column 20 ;
US 20040019039 A1