1-Boc-哌嗪合成路线

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MERCK SHARP and DOHME CORP.; SCHERING CORPORATION; SPERBECK, Donald, M.; DEVITA, Robert, J.; BALKOVEC, James, M.; GREENLEE, Mark, L.; WU, Zhicai; YU, Yang; VACHAL, Petr; ZHOU, Gang; WU, Heping; KUANG, Rongze; TING, Pauline; ASLANIAN, Robert
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6952-59-6间溴苯腈+

57260-71-61-Boc-哌嗪

807624-20-02-甲基-2-丙基4-(3-氰基苯基)-1-哌嗪羧酸酯

参考文献

Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R.
Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552

5190-68-14-氯喹唑啉+

57260-71-61-Boc-哌嗪

827598-29-8

参考文献

Xu, Lu; Russu, Wade A.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 540 - 546

2646-91-52,3-二氟苯甲醛+

57260-71-61-Boc-哌嗪

851753-43-0

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Jiang, Wanlong; Chen, Chen; Marinkovic, Dragan; Tran, Joe A.; Chen, Caroline W.; Arellano, L. Melissa; White, Nicole S.; Tucci, Fabio C.
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8924 - 8931

5413-85-44,6-二氯-5-氨基嘧啶+

57260-71-61-Boc-哌嗪

853679-43-3

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ARRAY BIOPHARMA INC.
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WO 2005/051304 A2

586-75-44-溴苯甲酰氯+

57260-71-61-Boc-哌嗪

867333-30-0

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TARGEGEN, INC.
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WO 2006/101977 A2

586-76-54-溴苯甲酸+

57260-71-61-Boc-哌嗪

867333-30-0

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SCHERING CORPORATION; DE LERA RUIZ, Manuel; BERLIN, Michael, Y.; ZHENG, Junying; ASLANIAN, Robert, G.; MCCORMICK, Kevin, D.; ZENG, Qingbei
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WO 2010/011653 A1

参考文献

ASTRAZENECA AB
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Location in patent: Page/Page column 11-13 ;
WO 2005/100325 A1

4025-64-33-氯磺酰基苯甲酸+

57260-71-61-Boc-哌嗪

874838-79-6

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Galley, Guido; Zbinden, Katrin Groebke; Norcross, Roger; Stalder, Henri
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590-28-3氰酸钾+

57260-71-61-Boc-哌嗪

883554-88-9

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Warner-Lambert Company LLC
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Location in patent: Page/Page column 59 ;
EP 1593679 A1