1-Boc-哌嗪合成路线

参考文献

BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd
Patent: WO2010/147653 A1, 2010 ;
Location in patent: Page/Page column 177 ;

886366-38-72-甲基-3-(4-Boc-哌嗪-1-基)-丙酸甲酯

参考文献

Raeppel, Stëphane; Raeppel, Franck; Claridge, Stephen William; Zhan, Lijie; Gaudette, Frëdëric; Mannion, Michael; Sato, Norifumi; Yuki, Yohei; Kishida, Masashi; Vaisburg, Arkadii
Patent: US2011/257100 A1, 2011 ;
US 20110257100 A1

140-88-5丙烯酸乙酯+

57260-71-61-Boc-哌嗪

886448-02-8

参考文献

Hoechst Marion Roussel, Inc.
Patent: US5977139 A1, 1999 ;
US 5977139 A

535-11-52-溴丙酸乙酯+

57260-71-61-Boc-哌嗪

886448-02-8

参考文献

Chiba, Jun; Takayama, Gensuke; Takashi, Tohru; Yokoyama, Mika; Nakayama, Atsushi; Baldwin, John J.; McDonald, Edward; Moriarty, Kevin J.; Sarko, Christopher R.; Saionz, Kurt W.; Swanson, Robert; Hussain, Zahid; Wong, Angela; MacHinaga, Nobuo
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 8 p. 2725 - 2746

118-48-9靛红酸酐+

57260-71-61-Boc-哌嗪

889125-00-22-甲基-2-丙基4-(2-氨基苯甲酰)-1-哌嗪羧酸酯

参考文献

Kamal, Ahmed; Tamboli, Jaki R.; Ramaiah, M. Janaki; Adil; KoteswaraRao; Viswanath; Mallareddy, Adla; Pushpavalli; Pal-Bhadra, Manika
ChemMedChem, 2012 , vol. 7, # 8 p. 1453 - 1464

2991-42-64-三氟甲基苯磺酰氯+

57260-71-61-Boc-哌嗪

793679-07-91-(4-三氟甲基苯磺酰基)-哌嗪盐酸盐

参考文献

Nettekoven, Matthias; Plancher, Jean-Marc; Richter, Hans; Roche, Olivier; Taylor, Sven
Patent: US2008/188484 A1, 2008 ;
Location in patent: Page/Page column 22 ;
US 20080188484 A1

845618-08-85-氯-2-三氟甲基咪唑+

57260-71-61-Boc-哌嗪

845618-09-9

参考文献

Pinard, Emmanuel; Alanine, Alexander; Alberati, Daniela; Bender, Markus; Borroni, Edilio; Bourdeaux, Patrick; Brom, Virginie; Burner, Serge; Fischer, Holger; Hainzl, Dominik; Halm, Remy; Hauser, Nicole; Jolidon, Synese; Lengyel, Judith; Marty, Hans-Peter; Meyer, Thierry; Moreau, Jean-Luc; Mory, Roland; Narquizian, Robert; Nettekoven, Mathias; Norcross, Roger D.; Puellmann, Bernd; Schmid, Philipp; Schmitt, Sebastien; Stalder, Henri; Wermuth, Roger; Wettstein, Joseph G.; Zimmerli, Daniel
Journal of Medicinal Chemistry, 2010 , vol. 53, # 12 p. 4603 - 4614

40161-54-44-溴-3-氟三氟甲苯+

57260-71-61-Boc-哌嗪

847547-01-7

参考文献

F. HOFFMANN-LA ROCHE AG
Patent: WO2005/23260 A1, 2005 ;
Location in patent: Page/Page column 43; 44 ;
WO 2005/023260 A1

32137-19-23,4-二氟三氟甲苯+

57260-71-61-Boc-哌嗪

847547-01-7

参考文献

CELLTECH R and D LIMITED
Patent: WO2004/113312 A1, 2004 ;
Location in patent: Page 29 ;

141738-80-9+

57260-71-61-Boc-哌嗪

847971-81-7

参考文献

F. HOFFMANN-LA ROCHE AG
Patent: WO2005/23260 A1, 2005 ;
Location in patent: Page/Page column 41 ;
WO 2005/023260 A1