1-Boc-哌嗪合成路线

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89402-42-62,3-二氟-5-(三氟甲基)吡啶+

57260-71-61-Boc-哌嗪

897376-76-0

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Jolidon, Synese; Narquizian, Robert; Norcross, Roger David; Pinard, Emmanuel
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1452-94-42-氯烟酸乙酯+

57260-71-61-Boc-哌嗪

900183-95-1

参考文献

Ognyanov, Vassil I.; Balan, Chenera; Bannon, Anthony W.; Bo, Yunxin; Dominguez, Celia; Fotsch, Christopher; Gore, Vijay K.; Klionsky, Lana; Ma, Vu V.; Qian, Yi-Xin; Tamir, Rami; Wang, Xianghong; Xi, Ning; Xu, Shimin; Zhu, Dawn; Gavva, Narender R.; Treanor, James J. S.; Norman, Mark H.
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78686-77-85-溴-6-氯烟酸甲酯+

57260-71-61-Boc-哌嗪

906559-32-8

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SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
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WO 2006/088919 A2

72093-07-35-氯-3-甲基吡啶+

57260-71-61-Boc-哌嗪

907208-89-34-(5-甲基吡啶-2-基)哌嗪-1-羧酸叔丁酯

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Zimmermann, Holger; Brueckner, David; Henninger, Kerstin; Hendrix, Martin; Radtke, Martin
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18368-64-42-氯-5-甲基吡啶+

57260-71-61-Boc-哌嗪

907208-89-34-(5-甲基吡啶-2-基)哌嗪-1-羧酸叔丁酯

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BAYER HEALTHCARE AG
Patent: WO2006/89664 A2, 2006 ;
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2651-46-94-氯丁基苯基醚+

57260-71-61-Boc-哌嗪

92493-11-31-(4-苯氧基丁基)哌嗪

参考文献

Eisai Co., Ltd.
Patent: EP1099692 A1, 2001 ;

64248-62-03,4-二氟苯腈+

57260-71-61-Boc-哌嗪

929884-77-5

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Janssen Pharmaceutica N.V.
Patent: WO2009/79593 A1, 2009 ;
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WO 2009/079593 A1

26452-80-22,4-二氯吡啶+

57260-71-61-Boc-哌嗪

936368-68-2

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ELI LILLY AND COMPANY
Patent: WO2007/53394 A1, 2007 ;
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WO 2007/053394 A1