1-Boc-哌嗪合成路线

参考文献

Gobbi, Luca; Jaeschke, Georg; Rodriguez Sarmiento, Rosa Maria; Steward, Lucinda
Patent: US2010/75979 A1, 2010 ;
Location in patent: Page/Page column 9; 11 ;
US 20100075979 A1

6226-25-12,2,2-三氟乙基三氟甲烷磺酸酯+

57260-71-61-Boc-哌嗪

692058-21-24-(2,2,2-三氟乙基)哌嗪-1-羧酸叔丁酯

参考文献

ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/41829 A1, 2004 ;
Location in patent: Page 75 ;
WO 2004/041829 A1

57260-71-61-Boc-哌嗪

945953-41-34-(2-氧代-乙基)-哌嗪-1-羧酸叔丁酯

参考文献

Johnson, Mark; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5826 - 5840

34784-04-85-溴异喹啉+

57260-71-61-Boc-哌嗪

444620-69-34-(5-异喹啉)-1-哌嗪羧酸 1,1-二甲基乙酯

参考文献

Kling, Andreas; Lange, Udo E. W.; Mack, Helmut; Bakker, Margot H. M.; Drescher, Karla U.; Hornberger, Wilfried; Hutchins, Charles W.; Moeller, Achim; Mueller, Reinhold; Schmidt, Martin; Unger, Liliane; Wicke, Karsten; Schellhaas, Kurt; Steiner, Gerd
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 24 p. 5567 - 5573

151-50-8氰化钾+

100-52-7苯甲醛+

57260-71-61-Boc-哌嗪

444891-21-84-(氰基(苯基)甲基)哌嗪-1-羧酸叔丁酯

参考文献

Bristol-Myers Squibb Company
Patent: US2007/78141 A1, 2007 ;
Location in patent: Page/Page column 17 ;

57260-71-61-Boc-哌嗪

444892-59-54-(2-氨基-1-(4-(三氟甲基)苯基)乙基)哌嗪-1-羧酸叔丁酯

参考文献

Fisher, Matthew J.; Backer, Ryan T.; Collado, Ivan; De Frutos, Oscar; Husain, Saba; Hsiung, Hansen M.; Kuklish, Steve L.; Mateo, Ana I.; Mullaney, Jeffrey T.; Ornstein, Paul L.; Paredes, Cristina Garcia; O'Brian, Thomas P.; Richardson, Timothy I.; Shah, Jikesh; Zgombick, John M.; Briner, Karin
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4973 - 4978

57260-71-61-Boc-哌嗪

474329-72-14-(2-硝基-4-(三氟甲基)苯基)哌嗪-1-羧酸叔丁酯

参考文献

BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KOWALSKI, Jennifer A.; MARSHALL, Daniel Richard; PROKOPOWICZ, Anthony S. III; SCHLYER, Sabine; SIBLEY, Robert; SORCEK, Ronald John; WU, Di; WU, Frank; YOUNG, Erick Richard Roush
Patent: WO2010/126811 A1, 2010 ;
Location in patent: Page/Page column 137-138 ;
WO 2010/126811 A1

3034-53-52-溴噻唑+

57260-71-61-Boc-哌嗪

474417-23-71-(2-噻唑)-4-(叔丁氧基羰基)哌嗪

参考文献

Di Malta, Alain; Garcia, Georges; Roux, Richard; Schoentjes, Bruno; Serradeil-Le Gal, Claudine; Tonnerre, Bernard; Wagnon, Jean
Patent: US2004/180878 A1, 2004 ;
Location in patent: Page/Page column 39 ;

131362-25-9+

57260-71-61-Boc-哌嗪

500013-36-5

参考文献

Ferring B.V.
Patent: EP1449844 A1, 2004 ;
Location in patent: Page 30 ;
EP 1449844 A1

参考文献

F. HOFFMANN-LA ROCHE AG
Patent: WO2009/53715 A1, 2009 ;
Location in patent: Page/Page column 106 ;
WO 2009/053715 A1