1-Boc-哌嗪合成路线

参考文献

BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 98; 105-106 ;

75-29-62-氯丙烷+

57260-71-61-Boc-哌嗪

414910-16-04-异丁基哌嗪-1-羧酸叔丁酯

参考文献

Alvaro, Giuseppe; Di Fabio, Romano; Maragni, Paolo; Tampieri, Marsia; Tranquillini, Maria Elvira
Patent: US2004/14770 A1, 2004 ;
Location in patent: Page/Page column 11 ;

79-30-1异丁酰氯+

57260-71-61-Boc-哌嗪

414910-16-04-异丁基哌嗪-1-羧酸叔丁酯

参考文献

SIENA BIOTECH S.P.A.; VARRONE, Maurizio; NENCINI, Arianna; QUINN, Joanna, Margaret; CARICASOLE, Andrea; BAKKER, Annette, Cornelia; GAVIRAGHI, Giovanni; SALERNO, Massimilano
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WO 2011/042145 A1

109-65-9正溴丁烷+

57260-71-61-Boc-哌嗪

412293-87-91-Boc-4-丁基哌嗪

参考文献

Meshram; Reddy, B. Chennakesava; Goud, P. Ramesh
Synthetic Communications, 2009 , vol. 39, # 13 p. 2297 - 2303

123-72-8丁醛+

57260-71-61-Boc-哌嗪

412293-87-91-Boc-4-丁基哌嗪

参考文献

Renau; Sanchez; Gage; Dever; Shapiro; Gracheck; Domagala
Journal of Medicinal Chemistry, 1996 , vol. 39, # 3 p. 729 - 735

4023-34-1环丙基甲酰氯+

57260-71-61-Boc-哌嗪

414910-15-94-(环丙烷羰基)哌嗪-1-羧酸叔丁酯

参考文献

BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 102 ;

57260-71-61-Boc-哌嗪+

1759-53-1环丙甲酸

414910-15-94-(环丙烷羰基)哌嗪-1-羧酸叔丁酯

参考文献

Giannini, Giuseppe; Battistuzzi, Gianfranco; Vesci, Loredana; Milazzo, Ferdinando M.; De Paolis, Francesca; Barbarino, Marcella; Guglielmi, Mario Berardino; Carollo, Valeria; Gallo, Grazia; Artali, Roberto; Dallavalle, Sabrina
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 462 - 466

234082-35-03-氯-4-氟苯甲酸甲酯+

57260-71-61-Boc-哌嗪

906559-46-43-氯-4-(4-Boc-1-哌嗪基)苯甲酸甲酯

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SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
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Location in patent: Page/Page column 142-143 ;
WO 2006/088919 A2