N-叔丁氧羰基-1,2-乙二胺合成路线 （共 68 条）
参考文献
ONCOTHERAPY SCIENCE, INC.; OHTANI, Mitsuaki; MATSUO, Yo; LI, Yingfu; WALKER, Joel, R.; JENKINS, David, M.; AHMED, Feryan; OHSAWA, Ryuji; HISADA, Shoji
Patent: WO2010/14794 A1, 2010 ;
Location in patent: Page/Page column 80 ;
WO 2010/014794 A1
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in methanol; acetonitrile T=20°C; 5 h;
参考文献
Bioorganic and medicinal chemistry, , vol. 11, # 2 p. 235 - 249
反应条件
triethylamine in tetrahydrofuran T=0°C; 4.5 h;
参考文献
Xu, Zhigang; DiCesare, John C.; Baures, Paul W.
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 2 p. 248 - 254
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 44, p. S498 - S500
反应条件
sodium hydrogencarbonate in water T=0 - 20°C; 1.5 h;
参考文献
YUAN, Ta Tung; CHUANG, Shih-Hsien; LIU, Tzu-Yin
Patent: WO2011/9047 A2, 2011 ;
Location in patent: Page/Page column 16-17 ;
反应条件
sodium hydrogencarbonate in water T=0 - 20°C;
参考文献
Foley, Timothy L.; Yasgar, Adam; Garcia, Christopher J.; Jadhav, Ajit; Simeonov, Anton; Burkart, Michael D.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 20 p. 4601 - 4606
反应条件
triethylamine in diethyl ether T=0 - 20°C; 4 h;
参考文献
Richter, Martin; Chakrabarti, Alokta; Ruttekolk, Ivo R.; Wiesner, Burkhard; Beyermann, Michael; Brock, Roland; Rademann, Joerg
Chemistry - A European Journal, 2012 , vol. 18, # 52 p. 16708 - 16715
反应条件
1: N,N-dimethyl-acetamide / 0.33 h / 60 °C 2: cobalt naphthenate, acetic anhydride / N,N-dimethyl-acetamide / 2 h / 70 - 80 °C View Scheme
参考文献
Corrie, John E. T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 20 p. 2975 - 2982
反应条件
triethylamine in tetrahydrofuran T=0 - 20°C; 73 h;
参考文献
US6903085 B1, ;
Page/Page column 77 ;
US 6903085 B1
反应条件
1.1: methanol / 20 °C / Molecular sieve 1.2: 16 h / -10 - 20 °C 2.1: triethylamine / chloroform / 16 h / 5 - 20 °C / Sealed tube 3.1: hydrogen / 20 palladium(II) hydroxide on carbon / water; methanol / 2.5 h View Scheme
