N-叔丁氧羰基-1,2-乙二胺合成路线 （共 68 条）
反应条件
1: 1.) Et3N, MgSO4, 2.) NaBH4 / 1.) MeOH, room temperature, 1.5 h, 2.) MeOH, -5 deg C (1.5 h), 0 deg C (1 h) 2: 100 percent / diisopropylethylamine / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 3 h 3: 91.3 percent / H2 / Pd/C / methanol / 4 h / 3102.9 Torr / Ambient temperature 4: 80 percent / aq. Et3N / acetonitrile / 4 h / Ambient temperature View Scheme
参考文献
Muller, Dan; Zeltser, Irena; Bitan, Gal; Gilon, Chaim
Journal of Organic Chemistry, 1997 , vol. 62, # 2 p. 411 - 416
参考文献
Mattei, Patrizio; Neidhart, Werner; Nettekoven, Matthias Heinrich; Pflieger, Philippe; Taylor, Sven
Patent: US2003/225141 A1, 2003 ;
Location in patent: Page 28 ;
反应条件
hydrogenchloride; sodium hydrogencarbonate; triethylamine; sodium chloride in dichloromethane; ethyl acetate
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US6545055 B1, 2003 ;
US 6545055 B1
反应条件
1: 1 N aq. NaOH / ethanol / 20 °C 2: 2.3 g / 1 N aq. NaOH / ethanol / 5 h / 20 °C / pH 9 - 10 View Scheme
参考文献
Cooper, Daniel C.; Suggs, J. William
Tetrahedron Letters, 2012 , vol. 53, # 51 p. 6943 - 6945
反应条件
(i) aq. NaOH, EtOH, (ii) /BRN= 509751/; Multistep reaction;
参考文献
Atherton,E. et al.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 3393 - 3396
反应条件
1: in methanol T=20°C; Molecular sieve; 2: With methanol; sodium tetrahydroborate T=-10 - 20°C; 16 h;
参考文献
PHARMACOFORE, INC.; JENKINS, Thomas, E.; HUSFELD, Craig, O.; SEROOGY, Julie, D.; WRAY, Jonathan, W.
Patent: WO2011/133150 A1, 2011 ;
Location in patent: Page/Page column 299-300 ;
反应条件
sodium tetrahydroborate; benzaldehyde; molecular sieve in methanol; ethyl acetate
参考文献
Jenkins, Thomas E.; Husfeld, Craig O.; Seroogy, Julie D.; Wray, Jonathan W.
Patent: US2011/262359 A1, 2011 ;
US 20110262359 A1
反应条件
triethylamine in tetrahydrofuran T=0°C;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2261213 A1, 2010 ;
Location in patent: Page/Page column 44 ;
EP 2261213 A1
反应条件
1:
2: With trifluoroacetic acid in dichloromethane
12 h;
参考文献
Wiget, Paul A.; Manzano, Lawrence A.; Pruet, Jeff M.; Gao, Grace; Saito, Ryota; Monzingo, Arthur F.; Jasheway, Karl R.; Robertus, Jon D.; Anslyn, Eric V.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6799 - 6804
反应条件
sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); biphenyl-2-yl-di-tert-butyl-phosphane in toluene
T=80°C; 2 h;
参考文献
Yamada, Rintaro; Seto, Minoru
Patent: US2005/20623 A1, 2005 ;
Location in patent: Page 93 ;
