5-(4-乙酰苯基)-呋喃-2-甲醛合成路线 （共 5 条）
反应条件
potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0) in ethanol; water; toluene
Suzuki coupling; 5 h; Heating;
参考文献
Mitsch, Andreas; Wissner, Pia; Silber, Katrin; Haebel, Peter; Sattler, Isabel; Klebe, Gerhard; Schlitzer, Martin
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4585 - 4600
反应条件
hydrogenchloride; copper dichloride; sodium nitrite
1.) H2O, 10 deg C, 0.5 h, 2.) H2O, 40 deg C, 20 h; Multistep reaction;
参考文献
Pong; Pelosi Jr.; Wessels; Yu; Burns; White; Anthony Jr.; Ellis; Wright; White Jr.
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 10 p. 1411 - 1416
反应条件
sodium acetate in acetic acid
参考文献
Yaremenko,F.G. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1977 , vol. 13, p. 1190 - 1194
Khimiya Geterotsiklicheskikh Soedinenii, 1977 , vol. 13, # 11 p. 1490 - 1494
反应条件
1: NH2OH*HCl / ethanol; H2O / 1 h
2: POCl3 / benzene / 1.5 h / Heating
View Scheme
参考文献
Pong; Pelosi Jr.; Wessels; Yu; Burns; White; Anthony Jr.; Ellis; Wright; White Jr.
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 10 p. 1411 - 1416
反应条件
1: NH2OH*HCl / ethanol; H2O / 1 h
2: POCl3 / benzene / 1.5 h / Heating
3: 91 percent / NaBH4 / Ambient temperature
View Scheme
参考文献
Pong; Pelosi Jr.; Wessels; Yu; Burns; White; Anthony Jr.; Ellis; Wright; White Jr.
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 10 p. 1411 - 1416
