2-(2-氧代吡咯烷-1-基)乙腈合成路线 （共 12 条）
反应条件
(NH4)2S in water T=20°C; 24 h;
参考文献
Kadushkin, A. V.; Golovko, T. V.; Granik, V. G.; Glushkov, R. G.; Parimbetova, R. B.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 10 p. 803 - 806
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 10 p. 1193 - 1196
反应条件
1: 68 percent / H2NOH*HCl, NaOEt / ethanol / 1 h / 20 °C 2: 85.4 percent / dioxane / 0.5 h / 0 - 5 °C View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 23, # 9 p. 779 - 784
Khimiko-Farmatsevticheskii Zhurnal, , vol. 23, # 9 p. 1147 - 1152
反应条件
1: 68 percent / H2NOH*HCl, NaOEt / ethanol / 1 h / 20 °C 2: 85.4 percent / dioxane / 0.5 h / 0 - 5 °C 3: 63 percent / 0.42 h / 150 °C View Scheme
参考文献
Glozman, O. M.; Voronina, T. A.; Orlova, E. K.; Meshchryakova, L. M.; Rakhmankulova, I. Kh.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 9 p. 779 - 784
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 9 p. 1147 - 1152
反应条件
sodium tetrahydroborate; nickel in methanol; sodium hydroxide 0.666667 h; Ambient temperature;
参考文献
Stezhko, T. V.; Granik, V. G.; Glushkov, R. G.; Roshchina, L. F.; Polezhaeva, A. I.; Mashkovskii, M. D.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 7 p. 478 - 482
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 7 p. 823 - 827
反应条件
diphosphorus pentasulfide; water 1.) xylene, reflux, 4 h, 2.) reflux, 30 min; Yield given. Multistep reaction;
参考文献
Granik, V. G.; Golovko, T. V.; Glushkov, R. G.; Mashovskii, M. D.; Roshchina, L. F.; et al.
Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 10 p. 795 - 802
Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 10 p. 1186 - 1193
参考文献
Zheltonogova, E. A.; Oleneva, G. I.; Shipov, A. G.; Baukov, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1990 , vol. 60, # 2.2 p. 474 - 475,412 - 413
参考文献
Zheltonogova, E. A.; Oleneva, G. I.; Shipov, A. G.; Baukov, Yu. I.
J. Gen. Chem. USSR (Engl. Transl.), 1990 , vol. 60, # 2.2 p. 474 - 475,412 - 413
反应条件
pyridine; N,N-dimethyl-formamide; trichlorophosphate
1.) acetonitrile, 50 deg C, 2.5 h, 2.) 0 deg C, 20 min; Yield given. Multistep reaction;
参考文献
Stezhko, T. V.; Granik, V. G.; Glushkov, R. G.; Roshchina, L. F.; Polezhaeva, A. I.; Mashkovskii, M. D.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 3 p. 154 - 161
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 3 p. 290 - 297
反应条件
1: 1.) POCl3 / 1.) benzene, room temp., 4.5 h, 2.) EtOH, 0.5 h
2: 35 percent / ethanol / 1 h / Heating
View Scheme
参考文献
Stezhko, T. V.; Granik, V. G.; Glushkov, R. G.; Roshchina, L. F.; Polezhaeva, A. I.; Mashkovskii, M. D.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 3 p. 154 - 161
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 3 p. 290 - 297
反应条件
1: 86 percent / CH2Cl2 / 5 h / Ambient temperature
2: 82 percent / ethanol / 2 h / 5 - 10 °C
View Scheme
参考文献
Stezhko, T. V.; Granik, V. G.; Glushkov, R. G.; Roshchina, L. F.; Polezhaeva, A. I.; Mashkovskii, M. D.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 3 p. 154 - 161
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 3 p. 290 - 297
