1: With hydrogenchloride; zinc(II) chloride in diethyl ether Houben-Hoesch reaction; 2 h; 2: in water 1 h; Heating;
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
1: sodium-<3,4,5-trimethoxy benzoate> / 180 °C / Erwaermen des Reaktionsprodukts mit wss.-aethanol. Kalilauge 2: acetic acid anhydride; aqueous hydriodic acid View Scheme
参考文献
Charlesworth; Robinson
Journal of the Chemical Society, 1933 , p. 268
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Badhwar; Kang; Venkataraman
Journal of the Chemical Society, 1932 , p. 1107,1108
1: trifluoromethylsulfonic anhydride; 2,4-dihydroxy-ω-methoxyacetophenone With 2,6-dimethylpyridine in dichloromethane
2 h;
2: 9-decyl-9-borabicyclo[3.3.1]nonane With potassium phosphate; tetrakis(triphenylphosphine) palladium(0); potassium bromide in tetrahydrofuran; water
T=65°C; Suzuki cross-coupling; 2 h;
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
1.1: 2,6-lutidine / CH2Cl2 / 2 h
1.2: Pd(PPh3)4; K3PO4; KBr / tetrahydrofuran; H2O / 2 h / 65 °C
2.1: 1.01 g / 4-(dimethylamino)pyridine; EDCI / CH2Cl2 / 20 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
1.1: 2,6-lutidine / CH2Cl2 / 2 h
1.2: Pd(PPh3)4; K3PO4; KBr / tetrahydrofuran; H2O / 2 h / 65 °C
2.1: 1.01 g / 4-(dimethylamino)pyridine; EDCI / CH2Cl2 / 20 °C
3.1: 88 percent / lithium hexamethyldisilylazide / tetrahydrofuran / 1 h / -20 °C
4.1: 69 percent / trimethylsilyl trifluoromethanesulfonate / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
