2,3,4-三甲氧基苯甲酸合成路线 （共 42 条）
参考文献
Dai, Ming; Yuan, Xing; Kang, Jian; Zhu, Zhi-Jun; Yue, Rong-Cai; Yuan, Hu; Chen, Bing-Yang; Zhang, Wei-Dong; Liu, Run-Hui; Sun, Qing-Yan
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 159 - 166
反应条件
phosphorus pentachloride; benzene
man leitet in erhaltene Loesung Ammoniak;
参考文献
Graebe; Suter
Justus Liebigs Annalen der Chemie, 1905 , vol. 340, p. 230
反应条件
1: benzene; PCl5 / man leitet in erhaltene Loesung Ammoniak
2: hypochlorite
View Scheme
参考文献
Graebe; Suter
Justus Liebigs Annalen der Chemie, 1905 , vol. 340, p. 230
参考文献
Lin; Liou; Ko; Teng
Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 11 p. 1109 - 1112
反应条件
1: nitric acid / 0.17 h / 0 °C
2: sulfuric acid / 110 °C / |Reflux
3: palladium 10 on activated carbon; hydrogen / ethanol / 12 h / 20 °C
4: sodium methylate / methanol; N,N-dimethyl-formamide / 24 h / 150 °C
5: trichlorophosphate; triethylamine / toluene / 3.5 h / 102 °C / |Inert atmosphere
View Scheme
参考文献
Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song
European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 23 - 34
反应条件
Yield given. Multistep reaction;
参考文献
Varache-Beranger, Martine; Nuchrich, Alain; Devaux, Guy
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 501 - 510
反应条件
boron trichloride in dichloromethane
T=0 - 20°C; 11 h; Inert atmosphere;
参考文献
Yanagisawa, Arata; Taga, Masashi; Atsumi, Toshiyuki; Nishimura, Koichiro; Ando, Kyoji; Taguchi, Tsuyoshi; Tsumuki, Hiroshi; Chujo, Iwao; Mohri, Shin-Ichiro
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 376 - 381
反应条件
1: sulfuryl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere
2: methanol; triethylamine / 0 °C
3: boron trichloride / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Yanagisawa, Arata; Taga, Masashi; Atsumi, Toshiyuki; Nishimura, Koichiro; Ando, Kyoji; Taguchi, Tsuyoshi; Tsumuki, Hiroshi; Chujo, Iwao; Mohri, Shin-Ichiro
Organic Process Research and Development, 2011 , vol. 15, # 2 p. 376 - 381
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C; 5 h;
参考文献
LEO PHARMA A/S
Patent: WO2008/77404 A1, 2008 ;
Location in patent: Page/Page column 44-45 ;
WO 2008/077404 A1
反应条件
sulfuric acid in methanol; water
参考文献
OHSHIMA, ETSUO; KAWAKITA, TAKASHI; YANAGAWA, KOJI; IIDA, KYOICHIRO; KOIKE, RIE; NAKASATO, YOSHISUKE; MATSUZAKI, TOHRU; OHMORI, KENJI; SATO, SOICHIRO; ISHII, HIDEE; MANABE, HARUHIKO; ICHIMURA, MICHIO; SUZUKI, FUMIO
Patent: US2002/128290 A1, 2002 ;
