反应条件
1: thionyl chloride / toluene / 2 h / Heating 2: 1 h / Heating 3: Na2CO3 / butan-1-ol / 1.5 h / Heating 4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating 5: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h 6: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h 7: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr 8: 2.) sodium cyanoborohydride / 1.) methanol, RT, 3.5 h, 2.) reflux View Scheme
参考文献
Kukla, Michael J.; Breslin, Henry J.; Pauwels, Rudi; Fedde, Cynthia L.; Miranda, Milton; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 746 - 751
