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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-溴-3-硝基苯甲酸
合成路线
（共 62 条）
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
126234-00-2
反应条件
1: thionyl chloride / toluene / 2 h / Heating 2: 1 h / Heating 3: Na2CO3 / butan-1-ol / 1.5 h / Heating 4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating 5: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h 6: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h 7: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr 8: 60 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 746 - 751
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
17726-57-7
反应条件
1: Na2CO3; Pd(Ph3)4; Et3N / dimethylformamide / 20 h / Heating 2: NH2NH2; Raney nickel / methanol 3: toluene / Heating 4: BF3*Et2O / 0 °C View Scheme
参考文献
Li, Jia-He; Serdyuk, Larisa; Ferraris, Dana V.; Xiao, Ge; Tays, Kevin L.; Kletzly, Paul W.; Li, Weixing; Lautar, Susan; Zhang, Jie; Kalish, Vincent J.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 13 p. 1687 - 1690
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
132933-14-3
反应条件
1: thionyl chloride / toluene / 2 h / Heating 2: 1 h / Heating 3: Na2CO3 / butan-1-ol / 1.5 h / Heating 4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating 5: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h 6: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h 7: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr 8: 50 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature View Scheme
参考文献
Kukla, Michael J.; Breslin, Henry J.; Pauwels, Rudi; Fedde, Cynthia L.; Miranda, Milton; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 746 - 751
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
126233-84-9
反应条件
1: thionyl chloride / toluene / 2 h / Heating 2: 1 h / Heating 3: Na2CO3 / butan-1-ol / 1.5 h / Heating 4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating 5: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h 6: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h 7: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr 8: 21 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 746 - 751
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
126234-03-5
反应条件
1: thionyl chloride / toluene / 2 h / Heating 2: 1 h / Heating 3: Na2CO3 / butan-1-ol / 1.5 h / Heating 4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating 5: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h 6: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h 7: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr 8: 40 percent / hydroxybenztriazole / dimethylformamide / 1.) 0 deg C, 1.5 h, 2.) RT, 2 d View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 746 - 751
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
126233-86-1
反应条件
1: thionyl chloride / toluene / 2 h / Heating 2: 1 h / Heating 3: Na2CO3 / butan-1-ol / 1.5 h / Heating 4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating 5: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h 6: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h 7: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr 8: 15 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature View Scheme
参考文献
Kukla, Michael J.; Breslin, Henry J.; Pauwels, Rudi; Fedde, Cynthia L.; Miranda, Milton; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 746 - 751
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
126233-96-3
反应条件
1: thionyl chloride / toluene / 2 h / Heating 2: 1 h / Heating 3: Na2CO3 / butan-1-ol / 1.5 h / Heating 4: 93 percent / 2-hydroxypyridine / xylene / 19 h / Heating 5: lithium aluminum hydride, conc. H2SO4 / tetrahydrofuran / 24 h 6: 71 percent / tetrahydrofuran / 1.) 0 deg C, 10 min, 2.) RT, 1 h 7: 87 percent / H2 / 10percent Pd/C / acetic acid / 6 h / 42 °C / 3102.9 Torr 8: 60 percent / potassium iodide, sodium carbonate / dimethylformamide / 22.5 h / Ambient temperature View Scheme
参考文献
Kukla, Michael J.; Breslin, Henry J.; Pauwels, Rudi; Fedde, Cynthia L.; Miranda, Milton; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 746 - 751
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
116529-60-3
2-溴-3,5-二硝基苯甲酸
反应条件
sulfuric acid; nitric acid
参考文献
Adams; Snyder
Journal of the American Chemical Society, 1938 , vol. 60, p. 1411,1413
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
119214-92-5
反应条件
1: 79 percent / Et3N / pyridine / 4 h / 25 °C 2: SOCl2, DMF / neat (no solvent) / 4 h / Heating 3: CH2Cl2 View Scheme
参考文献
Singh, Vijay P.; Singh, Harkesh B.; Butcher, Ray J.
European Journal of Organic Chemistry, 2011 , # 28 p. 5485 - 5497
573-54-6
2-溴-3-硝基苯甲酸
→
反应条件
36749-41-4
2-溴-3,5-二硝基-苯甲酸甲酯
反应条件
1: concentrated sulfuric acid; fuming nitric acid 2: hydrogen chloride View Scheme
参考文献
Adams; Snyder
Journal of the American Chemical Society, 1938 , vol. 60, p. 1411,1413
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