1,4-二氢-1,4-环氧萘合成路线 （共 84 条）
反应条件
1.1: ethyl acetate / 0.25 h / Reflux; Inert atmosphere
1.2: Reflux; Inert atmosphere
2.1: n-butyllithium / diethyl ether / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
3.1: toluene-4-sulfonic acid / ethanol / 11 h / Reflux; Inert atmosphere
View Scheme
参考文献
Guignard, Raphael F.; Zard, Samir Z.
Chemical Communications, 2011 , vol. 47, # 44 p. 12185 - 12187
反应条件
ammonia; lithium; tert-butyl alcohol in tetrahydrofuran
Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Paddon-Row, Michael N.; Hartcher, Robert
Australian Journal of Chemistry, 1980 , vol. 33, # 4 p. 785 - 794
反应条件
1: (i) benzene-1,4-diol, (ii) aq. HCl, MeOH
2: Se / 270 - 300 °C
View Scheme
参考文献
Wolthuis,E.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2215 - 2220
反应条件
1: 95 percent / 15 h / 140 - 145 °C / autoclave
2: 90 percent / conc. HCl / methanol / 15 h / Heating
3: 45 percent / CH3ONa / petroleum ether / 1.) 0 deg C, 2 h; 2.) RT, 15 h
View Scheme
参考文献
Mueller, Paul; Rey, Michel
Helvetica Chimica Acta, 1982 , vol. 65, # 4 p. 1157 - 1166
