4-乙酰基-4-溴代联苯合成路线 （共 24 条）
反应条件
lithium aluminium tetrahydride; aluminium trichloride
参考文献
Gray,G.W.; Mosley,A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1976 , p. 97 - 102
反应条件
1: AlCl3, LiAlH4 2: 1-methyl-pyrrolidin-2-one View Scheme
参考文献
Gray,G.W.; Mosley,A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1976 , p. 97 - 102
反应条件
1: With sodium hypobromide in 1,4-dioxane; water T=35 - 40°C; 2: With hydrogenchloride in water
参考文献
Kayani, Zohra N.; Lewis, Robert A.; Naseem, Shahzad
Journal of Molecular Liquids, 2012 , vol. 175, p. 72 - 84
反应条件
1: p-toluenesulfonic acid / benzene 2: 1.) Mg / 1.) THF, reflux, 12 h; 2.) room temp. View Scheme
参考文献
Sigman, Michael E.; Autrey, Tom; Schuster, Gary B.
Journal of the American Chemical Society, 1988 , vol. 110, # 13 p. 4297 - 4305
反应条件
1: 70percent HClO4, Tl(NO3)3 / Ambient temperature
2: 50 percent / NH3 / methanol / 96 h / Ambient temperature
3: 50 percent / t-BuOK / dimethylformamide / Ambient temperature
View Scheme
参考文献
Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714
反应条件
1: 47.3 percent / NaOCH3 / benzene / 1.) 5 deg C, 0.5 h, 2.) RT, 2 h
2: 17.5 percent / 2 N aq. NaOH / ethanol; dioxane / Ambient temperature
View Scheme
参考文献
Williams, H. W. R.; Eichler, E.; Randall, W. C.; Rooney, C. S.; Cragoe, E. J.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1196 - 1200
反应条件
1: hydrogenchloride; bromine; sodium hydroxide
2: sulfuric acid
View Scheme
参考文献
Kayani, Zohra N.; Lewis, Robert A.; Naseem, Shahzad
Journal of Molecular Liquids, 2012 , vol. 170, p. 11 - 19
反应条件
lithium aluminium tetrahydride
参考文献
Adrova,N.A. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1962 , p. 1711 - 1713
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1962 , # 10 p. 1804 - 1807
反应条件
bromine in dichloromethane
T=20°C; 48 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; DAS, Sanjoy Kumar; BENNANI, Youssef L.
Patent: WO2011/119853 A1, 2011 ;
Location in patent: Page/Page column 95 ;
反应条件
in methanol; dichloromethane
参考文献
Bigg, Dennis; Pommier, Jacques; Liberatore, Anne-Marie
Patent: US2004/77640 A1, 2004 ;
US 20040077640 A1
