4-乙酰基-4-溴代联苯合成路线 （共 24 条）
反应条件
copper(ll) bromide in chloroform; ethyl acetate
5 h; Reflux;
参考文献
Roman, Gheorghe; Vlahakis, Jason Z.; Vukomanovic, Dragic; Nakatsu, Kanji; Szarek, Walter A.
ChemMedChem, 2010 , vol. 5, # 9 p. 1541 - 1555
反应条件
1: S / Heating
2: aq. NaOH / ethanol
View Scheme
参考文献
IRM LLC; NOVARTIS AG; TELLEW, John Edward; WANG, Xia; WAN, Yongqin; XIE, Yun Feng; PAN, Shifeng; JIANG, Jiqing; XIE, Yongping; HUNT, Thomas Anthony; EDWARDS, Lee; BEATTIE, David; HEALY, Mark Patrick; WEST, Ryan; LISTER, Andrew Stuart
Patent: WO2012/138648 A1, 2012 ;
Location in patent: Page/Page column 74 ;
WO 2012/138648 A1
反应条件
dichloro[bis{1-(dicyclohexylphosphanyl)piperidine}]palladium; sodium carbonate in 1-methyl-pyrrolidin-2-one
T=140°C; 6 h; Inert atmosphere;
参考文献
Gerber, Roman; Oberholzer, Miriam; Frech, Christian M.
Chemistry - A European Journal, 2012 , vol. 18, # 10 p. 2978 - 2986
反应条件
1-methyl-pyrrolidin-2-one
T=185°C; 4 h;
参考文献
Thompson, Neil J.; Goodby, John W.; Toyne, Kenneth J.
Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1992 , vol. 213, p. 187 - 206
