5-甲基-2-巯基-1,3-二氢咪唑-4-羧酸乙酯合成路线 (共 2 条)
反应条件
1: in ethanol
2.5 h; Heating / reflux;
2: With trichlorophosphate in acetonitrile
60 h; Heating / reflux;
3: With sodium carbonate in chloroform; water
T=0°C;
参考文献
Actelion Phamaceuticals Ltd.
Patent: US2010/16401 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
ethanol
Erwaermen des entstandenen 2-Acetonylmercapto-5-methyl-1(3)H-imidazol-4-carbonsaeure-aethylester mit POCl3;
参考文献
Ochiai
Chemische Berichte, 1936 , vol. 69, p. 1650,1652