5-氯-2-甲基吲哚-3-羧醛合成路线 （共 5 条）
反应条件
1: 1.) triton B, 2.) conc. HCl / 1.) THF, reflux, 10 h, 2.) ethanol, room temp., 1 h 2: conc.H2SO4 / 1 h / Heating View Scheme
参考文献
Garuti; Giovanninetti; Bova; Chiarini
Archiv der Pharmazie, 1988 , vol. 321, # 7 p. 377 - 383
反应条件
1: ammonium acetate 2: sodium tris(acetoxy)borohydride / tetrahydrofuran 3: palladium 10 on activated carbon; ammonium formate / methanol View Scheme
参考文献
ChemMedChem, , vol. 7, # 7 p. 1286 - 1294
反应条件
hydrogenchloride; N-benzyl-trimethylammonium hydroxide 1.) THF, reflux, 10 h, 2.) ethanol, room temp., 1 h; Multistep reaction;
参考文献
Garuti; Giovanninetti; Bova; Chiarini
Archiv der Pharmazie, 1988 , vol. 321, # 7 p. 377 - 383
反应条件
1: With trichlorophosphate
T=10 - 50°C;
2: With sodium hydrogencarbonate in water
T=60°C; 0.25 h;
参考文献
Huesca, Mario; Young, Aiping H.; Lee, Yoon; Khine, Aye Aye; Wright, Jim A.; Lock, Lisa; Al-Qawasmeh, Raed
Patent: US2010/168417 A1, 2010 ;
Location in patent: Page/Page column 30 ;
反应条件
trichlorophosphate in N,N-dimethyl-formamide
参考文献
Baggett, Andrew W.; Cournia, Zoe; Han, Min Suk; Patargias, George; Glass, Adam C.; Liu, Shih-Yuan; Nolen, Brad J.
ChemMedChem, 2012 , vol. 7, # 7 p. 1286 - 1294
