2-氨基-4-羟基-6-乙基嘧啶合成路线 （共 10 条）
反应条件
sodium methylate in ethanol 2 h; Reflux;
参考文献
US2009/215777 A1, ;
Page/Page column 43; 48 ;
反应条件
potassium tert-butylate in methanol T=23 - 60°C;
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 6 p. 2429 - 2439
参考文献
Chemische Berichte, , vol. 71, p. 87,99
反应条件
trichlorophosphate T=70°C; 2 h;
参考文献
Caldwell; Ziegler
Journal of the American Chemical Society, 1936 , vol. 58, p. 287
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Todd et al.
Journal of the Chemical Society, 1936 , p. 1557
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Huber; Hoelscher
Chemische Berichte, 1938 , vol. 71, p. 87,99
反应条件
1: 90 percent / POCl3 / Heating 2: 35 percent aq. NH3 3: 56 percent / I2; aq. NaOH / CHCl3 / 5 h 4: 76 percent / Pd(OAc)2(dppf)2; aq. K2HPO4 / 1,2-dimethoxy-ethane / 24 h / Heating View Scheme
参考文献
Richardson, Marianne L.; Stevens, Malcolm F.G.
Journal of Chemical Research - Part S, 2002 , # 10 p. 482 - 484
参考文献
Todd et al.
Journal of the Chemical Society, 1936 , p. 1557
参考文献
The Upjohn Company
Patent: US3956302 A1, 1976 ;
反应条件
1: 90 percent / POCl3 / Heating
2: 35 percent aq. NH3
View Scheme
参考文献
Richardson, Marianne L.; Stevens, Malcolm F.G.
Journal of Chemical Research - Part S, 2002 , # 10 p. 482 - 484
反应条件
1: 90 percent / POCl3 / Heating
2: 35 percent aq. NH3
3: 56 percent / I2; aq. NaOH / CHCl3 / 5 h
View Scheme
参考文献
Richardson, Marianne L.; Stevens, Malcolm F.G.
Journal of Chemical Research - Part S, 2002 , # 10 p. 482 - 484
反应条件
1: 90 percent / POCl3 / Heating
2: methanol / Heating
View Scheme
参考文献
Richardson, Marianne L.; Stevens, Malcolm F.G.
Journal of Chemical Research - Part S, 2002 , # 10 p. 482 - 484
