5-溴-2-氰基-3-硝基吡啶合成路线 （共 21 条）
反应条件
in anhydrous propionitrile T=90°C; 17 h;
参考文献
US2012/165338 A1, ;
Page/Page column 22 ;
参考文献
EP1757594 A1, ;
Page/Page column 76 ;
EP 1757594 A1
反应条件
tert.-butylnitrite in acetonitrile T=60°C; 2 h;
参考文献
WO2004/55003 A1, ;
Page 65-66 ;
WO 2004/055003 A1
反应条件
in anhydrous propionitrile T=90°C; 17 h;
参考文献
WO2005/63690 A1, ;
Page/Page column 29 ;
WO 2005/063690 A1
反应条件
1: POBr3 / toluene / 80 °C 2: dimethylformamide / 120 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 13 p. 3608 - 3612
反应条件
1: sulfuric acid; sodium nitrite; water 2: bromine; phosphorus (III)-bromide / 100 °C View Scheme
参考文献
Journal of the Chemical Society, , p. 2042,2044
参考文献
Journal of the Chemical Society, , p. 2042,2044
反应条件
1.1: acetic acid; iron / 2 h / 80 °C 2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 - 5 °C 2.2: 1 h / Reflux View Scheme
参考文献
ORION CORPORATION; WOHLFAHRT, Gerd; TOeRMAeKANGAS, Olli; SALO, Harri; HOeGLUNG, Lisa; KARJALAINEN, Arja; KNUUTTILA, Pia; HOLM, Patrick; RASKU, Sirpa; VESALAINEN, Anniina
Patent: WO2011/51540 A1, 2011 ;
WO 2011/051540 A1
反应条件
1.1: 3-amino-5-bromopyridine-2-carboxylic acid / Raney Nickel / ethanol / 14 h / 20 °C 2.1: sodium hydroxide / water / 5 h / Reflux 2.2: 0 °C / pH 7 View Scheme
参考文献
Endo Pharmaceuticals Inc.; Smith, Roger Astbury; Venkatesan, Aranapakam; Bejugam, Mallesham; Hoshalli, Subramanya; Nanduri, Srinivas
Patent: US2014/38952 A1, 2014 ;
反应条件
1: With sulfuric acid; tetrabutyl ammonium fluoride in N,N-dimethyl-formamide T=-40°C; 1 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide T=-40°C; pH=3;
参考文献
US2012/165338 A1, ;
Page/Page column 22 ;
