5-溴-3-羟基异吲哚啉-1-酮合成路线 （共 4 条）
反应条件
hydrazine T=95°C; 5 h;
参考文献
WO2008/61108 A2, ;
Page/Page column 55 ;
反应条件
1: With sodium hydroxide; copper(II) sulfate; zinc in water
T=0 - 20°C; 3 h;
2: With hydrogenchloride in water
pH=7;
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2005/103039 A1, 2005 ;
Location in patent: Page/Page column 32 ;
WO 2005/103039 A1
反应条件
silver nitrate in water; acetonitrile
112 h; Heating / reflux;
参考文献
Amgen Inc.
Patent: US2006/199817 A1, 2006 ;
Location in patent: Page/Page column 22; 23 ;
US 20060199817 A1
参考文献
Dow AgroSciences LLC; Lo, William C.; Hunter, James E.; Watson, Gerald B.; Patny, Akshay; Iyer, Pravin S.; Boruwa, Joshodeep
Patent: US2014/171314 A1, 2014 ;
Location in patent: Page/Page column ;
