(S)-1-cbz-3-吡咯烷羧酰胺合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 3 h;
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
Location in patent: Page/Page column 60-61 ;
反应条件
dihydrogen peroxide; sodium carbonate in water; acetone
T=20°C; 18 h;
参考文献
Dermatakis, Apos; Luk, Kin-Chun; DePinto, Wanda
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1873 - 1881
反应条件
1: tetrahydrofuran / -25 - 0 °C
2: 2.1 g / Bu4NCN / dimethylsulfoxide / 20 h / 60 °C
3: 57 percent / H2O2; Na2CO3 / acetone; H2O / 18 h / 20 °C
View Scheme
参考文献
Dermatakis, Apos; Luk, Kin-Chun; DePinto, Wanda
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1873 - 1881
反应条件
1: 2.1 g / Bu4NCN / dimethylsulfoxide / 20 h / 60 °C
2: 57 percent / H2O2; Na2CO3 / acetone; H2O / 18 h / 20 °C
View Scheme
参考文献
Dermatakis, Apos; Luk, Kin-Chun; DePinto, Wanda
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 8 p. 1873 - 1881
反应条件
1: triethylamine / acetonitrile / 24 h / 0 - 20 °C / Inert atmosphere
2: triethylamine / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere
3: dimethyl sulfoxide / 21 h / 80 °C / Inert atmosphere
4: water; sodium carbonate; dihydrogen peroxide / acetone / 20 h / 20 °C
View Scheme
参考文献
FOB SYNTHESIS; CHOI, Woo-Baeg; KIM, Deog-Il; GRUSZECKA-KOWALIK, Ewa; JOO, Hyung-Yeul; LIU, Shuangpei; MAO, Shuli; LI, Yongfeng
Patent: WO2011/160020 A2, 2011 ;
