3-氟-5-氨基吡啶-2-甲酸合成路线 （共 7 条）
反应条件
iron; acetic acid T=65°C;
参考文献
Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: US2013/29962 A1, 2013 ;
Location in patent: Paragraph 0791 ;
反应条件
in acetic acid; ethyl acetate
参考文献
US2004/77605 A1, ;
US 20040077605 A1
反应条件
iron; acetic acid T=40°C;
参考文献
Duan, Maosheng; Kazmierski, Wieslaw M.; Chong, Pek Y.; DeAnda, Felix; Edelstein, Mark; Ferris, Rob; Peckham, Jennifer; Wheelan, Pat; Xiong, Zhiping; Zhang, Huichang; Nishizawa, Rena; Takaoka, Yoshikazu
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6470 - 6475
反应条件
1: urea hydrogen peroxide addition compound; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C 2: tetra-n-butylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 0 °C 3: iron; acetic acid / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6470 - 6475
反应条件
1: tetra-n-butylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 0 °C 2: iron; acetic acid / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6470 - 6475
反应条件
1: hydrogenchloride; water 2: sulfuric acid / |Reflux View Scheme
参考文献
Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: US2013/29962 A1, 2013 ;
反应条件
hydrogenchloride; water
参考文献
Gruenenthal GmbH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: US2013/29962 A1, 2013 ;
Location in patent: Paragraph 0792 ;
