1-异丙基-2H-3,1-苯并恶嗪-2,4(1H)-二酮合成路线 （共 7 条）
反应条件
in dichloromethane
T=0 - 20°C; 16 h;
参考文献
SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; MOHAMMED, Abdul, Rasheed; AHMAD, Ishtiyaque; JAYARAJAN, Pradeep; KANDIKERE, Nagaraj, Vishwottam; SHINDE, Anil, Karbhari; KAMBHAMPATI, Rama, Sastri; BHYRAPUNENI, Gopinadh; RAVULA, Jyothsna; PATNALA, Sriramachandra, Murthy; JASTI, Venkateswarlu
Patent: WO2011/30349 A1, 2011 ;
Location in patent: Page/Page column 39-40 ;
WO 2011/030349 A1
反应条件
1.1: thionyl chloride / 18.5 h / 0 - 20 °C
1.2: Cooling with ice
2.1: acetic acid / dichloromethane / 0.25 h / 0 °C
2.2: 16 h / 0 - 20 °C
3.1: sodium hydroxide / water; methanol / 16 h / 0 °C / Reflux
4.1: dichloromethane / 16 h / 0 - 20 °C
View Scheme
参考文献
SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; MOHAMMED, Abdul, Rasheed; AHMAD, Ishtiyaque; JAYARAJAN, Pradeep; KANDIKERE, Nagaraj, Vishwottam; SHINDE, Anil, Karbhari; KAMBHAMPATI, Rama, Sastri; BHYRAPUNENI, Gopinadh; RAVULA, Jyothsna; PATNALA, Sriramachandra, Murthy; JASTI, Venkateswarlu
Patent: WO2011/30349 A1, 2011 ;
WO 2011/030349 A1
反应条件
1.1: acetic acid / dichloromethane / 0.25 h / 0 °C
1.2: 16 h / 0 - 20 °C
2.1: sodium hydroxide / water; methanol / 16 h / 0 °C / Reflux
3.1: dichloromethane / 16 h / 0 - 20 °C
View Scheme
参考文献
SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; MOHAMMED, Abdul, Rasheed; AHMAD, Ishtiyaque; JAYARAJAN, Pradeep; KANDIKERE, Nagaraj, Vishwottam; SHINDE, Anil, Karbhari; KAMBHAMPATI, Rama, Sastri; BHYRAPUNENI, Gopinadh; RAVULA, Jyothsna; PATNALA, Sriramachandra, Murthy; JASTI, Venkateswarlu
Patent: WO2011/30349 A1, 2011 ;
WO 2011/030349 A1
反应条件
1: sodium hydroxide / water; methanol / 16 h / 0 °C / Reflux
2: dichloromethane / 16 h / 0 - 20 °C
View Scheme
参考文献
SUVEN LIFE SCIENCES LIMITED; NIROGI, Ramakrishna; MOHAMMED, Abdul, Rasheed; AHMAD, Ishtiyaque; JAYARAJAN, Pradeep; KANDIKERE, Nagaraj, Vishwottam; SHINDE, Anil, Karbhari; KAMBHAMPATI, Rama, Sastri; BHYRAPUNENI, Gopinadh; RAVULA, Jyothsna; PATNALA, Sriramachandra, Murthy; JASTI, Venkateswarlu
Patent: WO2011/30349 A1, 2011 ;
WO 2011/030349 A1
参考文献
Ozaki; Yamada; Oine; Ishizuka; Iwasawa
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 568 - 576
反应条件
(i) NaH, AcNMe2, (ii) /BRN= 1098244/; Multistep reaction;
参考文献
Hardtmann; Koletar; Pfister
Journal of Heterocyclic Chemistry, 1975 , vol. 12, # 3 p. 565 - 572
反应条件
(i) H2, Pd-C, (ii) /BRN= 1098367/, aq. NaOH, CO2, benzene; Multistep reaction;
参考文献
Hardtmann; Koletar; Pfister
Journal of Heterocyclic Chemistry, 1975 , vol. 12, # 3 p. 565 - 572
