2,2,2-三氯丁酸乙酯合成路线 （共 12 条）
反应条件
in N,N-dimethyl-formamide T=45°C; 144 h; subtilisin;
参考文献
Riva,S.; Choipineau,J.; Kieboom,A.P.
Journal of the American Chemical Society, 1988 , vol. 110, p. 584
反应条件
in benzene T=25°C; 120 h; lipase Amano P/Celite 577; Yields of byproduct given;
参考文献
Bianchi, Daniele; Cesti, Pietro; Battistel, Ezio
Journal of Organic Chemistry, 1988 , vol. 53, # 23 p. 5531 - 5534
反应条件
in diethyl ether T=35°C; Candida cylindracea lipase;
参考文献
Hogan, V F; O'Hagan, D; Sanvoisin, J
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 12 p. 883 - 885
反应条件
in diethyl ether T=35°C; Candida cylindracea lipase;
参考文献
Hogan, V F; O'Hagan, D; Sanvoisin, J
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 12 p. 883 - 885
反应条件
porcine pancreatic lipase in n-heptane T=60°C; 336 h;
参考文献
Journal of Organic Chemistry, , vol. 53, # 10 p. 2374 - 2378
反应条件
in pyridine
T=25°C; 24 h;
参考文献
Perrone, Gabriel G.; Barrow, Kevin D.; McFarlane, Ian J.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 5 p. 831 - 835
反应条件
tetrachloromethane; aluminum isopropoxide
参考文献
Lin; Day
Journal of the American Chemical Society, 1952 , vol. 74, p. 5133
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine
T=0°C;
参考文献
Theil, Fritz; Schick, Hans; Lapitskaya, Margarita A.; Pivnitsky, Kasimir K.
Liebigs Annalen der Chemie, 1991 , # 3 p. 195 - 200
→
121104-96-9[(1S,6S,7S,8R,8aR)-1,7,8-三羟基-1,2,3,5,6,7,8,8a-八氢吲嗪-6-基] 丁酸酯
反应条件
in pyridine
T=45°C; 96 h; porcine pancreatic lipase (EC 3.1.1.3);
参考文献
Margolin; Delinck; Whalon
Journal of the American Chemical Society, 1990 , vol. 112, # 8 p. 2849 - 2854
反应条件
in toluene
144 h; enzyme-catalyyed transesterification, enzyme: commercial Candida rugosa lipase; Yield given;
参考文献
Persichetti, Rose A.; Lalonde, Jim J.; Govardhan, Chandrika P.; Khalaf, Nazer K.; Margolin, Alexey L.
Tetrahedron Letters, 1996 , vol. 37, # 36 p. 6507 - 6510
