2-氨基嘧啶-5-甲酸乙脂合成路线 （共 12 条）
反应条件
ammonium hydroxide in acetonitrile T=20°C;
参考文献
CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria
Patent: WO2013/45280 A1, 2013 ;
Location in patent: Page/Page column 276 ;
参考文献
Journal of the American Chemical Society, , vol. 64, p. 794,797
反应条件
sodium ethanolate in ethanol 4 h; Heating;
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
1: H2O; chlorine 2: NH3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 64, p. 794,797
反应条件
1: aqueous ethanol; zinc-powder 2: H2O; chlorine 3: NH3 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 64, p. 794,797
参考文献
Vartanyan, R. S.; Kazaryan, Zh. V.; Vartanyan, S. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1982 , vol. 18, # 11 p. 1212 - 1213
Khimiya Geterotsiklicheskikh Soedinenii, 1982 , vol. 18, # 11 p. 1558 - 1559
反应条件
1.1: acetic acid; zinc / tetrahydrofuran / |Reflux 1.2: 20 °C 2.1: ammonium hydroxide / acetonitrile / 20 °C View Scheme
反应条件
1.1: Na; EtOH / benzene / 2 h / 0 °C 1.2: 58 percent / benzene / 3 h / 50 °C 2.1: 66 percent / aq. HCl / ethanol / Heating 3.1: Br2; AcOH / 1.5 h / Heating 4.1: POCl3; N,N-dimethylaniline / 1.5 h / Heating 5.1: ethanolic NH3 / 1 h / 100 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1504 - 1513
反应条件
1: 66 percent / aq. HCl / ethanol / Heating 2: Br2; AcOH / 1.5 h / Heating 3: POCl3; N,N-dimethylaniline / 1.5 h / Heating 4: ethanolic NH3 / 1 h / 100 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1504 - 1513
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C 2: ammonium hydroxide / water; acetonitrile / 20 °C View Scheme
