1,5-二甲基-1H-吡唑-3-甲酸乙酯合成路线 （共 14 条）
反应条件
1: ethyl 3-methyl-5-pyrazolecarboxylate With sodium hydride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: methyl iodide in tetrahydrofuran T=20°C; 12 h; Inert atmosphere; regioselective reaction;
参考文献
Seubert, Christoph K.; Sun, Yu; Lan, Yanhua; Powell, Annie K.; Thiel, Werner R.
European Journal of Inorganic Chemistry, 2011 , # 11 p. 1768 - 1775
反应条件
in ethanol T=0°C; 1.5 h; Inert atmosphere;
参考文献
Schiess, Raphael; Gertsch, Juerg; Schweizer, W. Bernd; Altmann, Karl-Heinz
Organic Letters, 2011 , vol. 13, # 6 p. 1436 - 1439
反应条件
1.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C 1.2: 31 percent / tetrahydrofuran / 1.5 h / -78 - -40 °C 2.1: CDCl3 / 2 h / 100 °C / microwave irradiation View Scheme
参考文献
Organic Letters, , vol. 8, # 15 p. 3219 - 3222
反应条件
benzene T=100°C; <Als Hauptprodukt>;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 143, p. 259,273
Journal of Organic Chemistry, , vol. 30, p. 199,202
反应条件
in chloroform-d1 T=100°C; 2 h; microwave irradiation;
参考文献
Organic Letters, , vol. 8, # 15 p. 3219 - 3222
反应条件
in ethanol 3 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 68, # 15 p. 5977 - 5982
反应条件
in ethanol 0.5 h; Heating;
参考文献
Australian Journal of Chemistry, , vol. 36, # 1 p. 135 - 147
反应条件
sulfuric acid; sodium carbonate
参考文献
Chemische Berichte, , vol. 59, p. 1299
反应条件
2 h; Heating; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Heterocyclic Chemistry, , vol. 36, # 1 p. 217 - 220
反应条件
sodium hydroxide in ethanol; water 1 h; Heating;
参考文献
Huppatz
Australian Journal of Chemistry, 1983 , vol. 36, # 1 p. 135 - 147
