1,3-二甲基-1氢-吡唑-5-甲酸合成路线 （共 14 条）
反应条件
1: 78 percent / conc. H2SO4, 90percent aq. HNO3 / 2.5 h / 80 - 100 °C
2: SOCl2 / 3.5 h / Heating
3: aq. NH4OH / acetone
View Scheme
参考文献
Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5097 - 5104
参考文献
Genentech, Inc.
Patent: US2011/86840 A1, 2011 ;
反应条件
1: SOCl2 / Heating
2: pyridine / Heating
View Scheme
参考文献
Huppatz; Phillips; Witrzens
Agricultural and Biological Chemistry, 1984 , vol. 48, # 1 p. 45 - 50
反应条件
sulfuric acid; nitric acid
T=60°C; 4 h; Inert atmosphere;
参考文献
Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5097 - 5104
