3-(吡咯烷-2-基)吡啶合成路线 （共 38 条）
反应条件
1.1: sodium hydride / tetrahydrofuran / 1 h / Heating 1.2: 72 percent / aq. HCl / Heating 2.1: 81 percent / NaBH4 / methanol; acetic acid / -40 - 20 °C 3.1: Et3N; H2 / Pd/C / ethanol / 760.05 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 12 p. 4115 - 4121
反应条件
1: 81 percent / NaBH4 / methanol; acetic acid / -40 - 20 °C 2: Et3N; H2 / Pd/C / ethanol / 760.05 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 12 p. 4115 - 4121
反应条件
tetrahydrofuran; lithium aluminium tetrahydride
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 292, p. 9,13
Journal of the American Chemical Society, , vol. 80, p. 1634
反应条件
1: 2-amino-2-(pyridin-3-yl)acetonitrile With potassium hexamethylsilazane in tetrahydrofuran T=-78°C; 0.05 h; 2: acrolein in tetrahydrofuran T=-78°C; 0.5 h; 3: With sodium cyanoborohydride; acetic acid in tetrahydrofuran; ethanol T=25°C;
参考文献
Synthesis, , # 6 art. no. T11904SS, p. 945 - 956
反应条件
sodium periodate; RuO4 in tetrachloromethane; water 6 h;
参考文献
Archiv der Pharmazie, , vol. 317, # 1 p. 21 - 27
反应条件
1: zinc-powder; acetic acid; ethanol 2: LiAlH4; THF View Scheme
参考文献
Journal of the American Chemical Society, , vol. 80, p. 1634
反应条件
1: 87 percent / Na2CO3 / H2O / 20 °C 2: Li; DTBB / tetrahydrofuran / 2 h / -78 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 18 p. 6207 - 6208
反应条件
1: benzene / 16 h / Heating 2: 2.4 M n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 - -45 °C 3: 1.) 10percent aq. HCl, 2.) K2CO3, 40percent aq. KOH / 1.) THF, hexane, water, 15-20 min, room temp., 2.) water, pH 10-12 View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 8 p. 1137 - 1140
反应条件
1: 2.4 M n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 - -45 °C 2: 1.) 10percent aq. HCl, 2.) K2CO3, 40percent aq. KOH / 1.) THF, hexane, water, 15-20 min, room temp., 2.) water, pH 10-12 View Scheme
参考文献
Tetrahedron Letters, , vol. 37, # 8 p. 1137 - 1140
反应条件
1: 80 percent 2: 65 percent / hydrazoic acid, conc. sulfuric acid / CH2Cl2 / 0 °C / substrate: 1-(3-pyridyl) cyclopentanol 3: 68 percent / sodium cyanoborohydride / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 24, # 18 p. 1937 - 1940
