3-(吡咯烷-2-基)吡啶合成路线 （共 38 条）
反应条件
1: 3-pyrrolidin-2-yl-pyridine With n-butyllithium in tetrahydrofuran T=-70°C; Metallation; 0.25 h; 2: trideuteriomethyl iodide T=-70 - 0°C; Substitution;
参考文献
Crooks, Peter A.; Ravard, Alain; Byrd, Gary D.
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 12 p. 1165 - 1171
反应条件
zirconium oxide 5 h; Heating;
参考文献
Takahashi, Kyoko; Shibagaki, Makoto; Matsushita, Hajime
Agricultural and Biological Chemistry, 1988 , vol. 52, # 3 p. 853 - 854
反应条件
sodium cyanoborohydride in acetonitrile
参考文献
Murahashi, Shun-Ichi; Mitsui, Hitoshi; Shiota, Tatsuki; Tsuda, Tomoyasu; Watanabe, Shoji
Journal of Organic Chemistry, 1990 , vol. 55, # 6 p. 1736 - 1744
反应条件
1: in water T=85°C; 20 h; 2: With sodium hydroxide in water pH=13;
参考文献
Divi's Laboratories Limited
Patent: US2012/209006 A1, 2012 ;
Location in patent: Page/Page column 3 ;
反应条件
ESCHWEILER-method; Yield given;
参考文献
Alberici, Gilles F.; Andrieux, Jean; Adam, Gerard; Plat, Michel M.
Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1937 - 1940
反应条件
formic acid in water 16 h; Inert atmosphereReflux; optical yield given as percent ee;
参考文献
Barker, Graeme; McGrath, Julia L.; Klapars, Artis; Stead, Darren; Zhou, George; Campos, Kevin R.; O'Brien, Peter
Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 5936 - 5953
反应条件
formic acid in water 16 h; Inert atmosphereReflux; optical yield given as percent ee;
参考文献
Barker, Graeme; McGrath, Julia L.; Klapars, Artis; Stead, Darren; Zhou, George; Campos, Kevin R.; O'Brien, Peter
Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 5936 - 5953
反应条件
2: LiAlH4 / diethyl ether
View Scheme
参考文献
Braumann, Thomas; Nicolaus, Gerd; Hahn, Wolfgang; Elmenhorst, Hinrich
Phytochemistry (Elsevier), 1990 , vol. 29, # 11 p. 3693 - 3694
