1-(4-溴苯基)-2-甲基丙烷-2-醇合成路线 （共 10 条）
反应条件
1: With methylmagnesium bromide in diethyl ether
T=0 - 20°C; 2 h;
2: With ammonium chloride in water
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/108676 A1, 2004 ;
Location in patent: Page 142 ;
WO 2004/108676 A1
反应条件
1: in tetrahydrofuran
T=0°C; 3.25 h;
2: With water; ammonium chloride in tetrahydrofuran
参考文献
PFIZER INC.; ASPNES, Gary, Erik; DOW, Robert, Lee; MUNCHHOF, Michael, John
Patent: WO2010/86820 A1, 2010 ;
Location in patent: Page/Page column 53-54 ;
WO 2010/086820 A1
反应条件
1: in tetrahydrofuran; diethyl ether
T=0°C; 2 h;
2: With hydrogenchloride; water in tetrahydrofuran; diethyl ether
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1813611 A1, 2007 ;
Location in patent: Page/Page column 26 ;
反应条件
methylmagnesium bromide in tetrahydrofuran; diethyl ether; toluene
参考文献
Hoffmann-La Roche Inc.
Patent: US6150373 A1, 2000 ;
US 6150373 A
反应条件
isopropyl alcohol
T=20°C; Irradiation; Title compound not separated from byproducts;
参考文献
Tomioka, Hideo; Suzuki, Shinji; Izawa, Yasuji
Journal of the American Chemical Society, 1982 , vol. 104, # 4 p. 1047 - 1050
反应条件
isopropyl alcohol
T=20°C; Irradiation;
参考文献
Tomioka, Hideo; Suzuki, Shinji; Izawa, Yasuji
Journal of the American Chemical Society, 1982 , vol. 104, # 4 p. 1047 - 1050
参考文献
Landis; VanderWerf
Journal of the American Chemical Society, 1958 , vol. 80, p. 5277,5278
反应条件
in diethyl ether
RefluxInert atmosphere;
参考文献
Lu, Yi; Wang, Dong-Hui; Engle, Keary M.; Yu, Jin-Quan
Journal of the American Chemical Society, 2010 , vol. 132, # 16 p. 5916 - 5921
反应条件
in solid matrix
T=-196°C; Irradiationtemperature dependence of product distributions, added sensitizer; Product distribution;
参考文献
Tomioka, Hideo; Suzuki, Shinji; Izawa, Yasuji
Journal of the American Chemical Society, 1982 , vol. 104, # 11 p. 3156 - 3162
反应条件
Ambient temperatureIrradiationrelative yields of products for different substituents;
参考文献
Tomioka, Hideo; Tabayashi, Kazuo; Ozaki, Yasuji; Izawa, Yasuji
Tetrahedron, 1985 , vol. 41, # 8 p. 1435 - 1440
