4-氯-7-甲氧基喹唑啉-6-醇合成路线 （共 9 条）
反应条件
ammonia in methanol
T=20°C; 1.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/26151 A1, 2005 ;
Location in patent: Page/Page column 124 ;
WO 2005/026151 A1
反应条件
tetrachloromethane; triphenylphosphine in 1,2-dichloro-ethane
T=80°C;
参考文献
Pham, Helen Trinh; Hanson, Robert N.; Olmsted, Sandra L.; Kozhushnyan, Anton; Visentin, Adam; Weglinsky, Paul J.; Massero, Chris; Bailey, Kristen
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1053 - 1056
反应条件
1: With thionyl chloride; N,N-dimethyl-formamide
T=80°C; 1.5 h;
2: With methanol; ammonia in dichloromethane; water
T=80°C; 0.0833333 h;
3: With hydrogenchloride in water
pH=7;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/41829 A1, 2004 ;
Location in patent: Page 88 ;
WO 2004/041829 A1
反应条件
1: nitric acid; tin(IV) chloride / dichloromethane / 20 °C / Cooling with ethylene glycol-dry ice
2: sodium dithionite / methanol; water / 2 h / 55 - 65 °C
3: formamide / 16 h / 150 °C
4: tetrachloromethane; triphenylphosphine / 1,2-dichloro-ethane / 80 °C
View Scheme
参考文献
Pham, Helen Trinh; Hanson, Robert N.; Olmsted, Sandra L.; Kozhushnyan, Anton; Visentin, Adam; Weglinsky, Paul J.; Massero, Chris; Bailey, Kristen
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1053 - 1056
反应条件
1: sodium dithionite / methanol; water / 2 h / 55 - 65 °C
2: formamide / 16 h / 150 °C
3: tetrachloromethane; triphenylphosphine / 1,2-dichloro-ethane / 80 °C
View Scheme
参考文献
Pham, Helen Trinh; Hanson, Robert N.; Olmsted, Sandra L.; Kozhushnyan, Anton; Visentin, Adam; Weglinsky, Paul J.; Massero, Chris; Bailey, Kristen
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1053 - 1056
反应条件
1: formamide / 16 h / 150 °C
2: tetrachloromethane; triphenylphosphine / 1,2-dichloro-ethane / 80 °C
View Scheme
参考文献
Pham, Helen Trinh; Hanson, Robert N.; Olmsted, Sandra L.; Kozhushnyan, Anton; Visentin, Adam; Weglinsky, Paul J.; Massero, Chris; Bailey, Kristen
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1053 - 1056
反应条件
1: potassium carbonate / acetone; toluene / 7 h / Reflux
2: nitric acid; tin(IV) chloride / dichloromethane / 20 °C / Cooling with ethylene glycol-dry ice
3: sodium dithionite / methanol; water / 2 h / 55 - 65 °C
4: formamide / 16 h / 150 °C
5: tetrachloromethane; triphenylphosphine / 1,2-dichloro-ethane / 80 °C
View Scheme
参考文献
Pham, Helen Trinh; Hanson, Robert N.; Olmsted, Sandra L.; Kozhushnyan, Anton; Visentin, Adam; Weglinsky, Paul J.; Massero, Chris; Bailey, Kristen
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1053 - 1056
反应条件
di-tert-butylazodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; Mitsunobu reaction; 12 h;
参考文献
Tasler, Stefan; Mueller, Oliver; Wieber, Tanja; Herz, Thomas; Pegoraro, Stefano; Saeb, Wael; Lang, Martin; Krauss, Rolf; Totzke, Frank; Zirrgiebel, Ute; Ehlert, Jan E.; Kubbutat, Michael H.G.; Schaechtele, Christoph
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6728 - 6737
反应条件
2,2'-azo-bisisobutyronitrile; triphenylphosphine in dichloromethane
T=20°C; 3 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/41829 A1, 2004 ;
Location in patent: Page 88-89 ;
WO 2004/041829 A1
