2-(2-氯苯基)-1-苯基乙烷-1-酮合成路线 （共 11 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane in N,N-dimethyl-formamide T=90°C; 24 h;
参考文献
Qi, Chaorong; Jiang, Huanfeng; Huang, Liangbin; Chen, Zhengwang; Chen, Huoji
Synthesis, 2011 , # 3 art. no. F17110SS, p. 387 - 396
反应条件
in tetrahydrofuran
T=-78°C; 5 h; Inert atmosphere;
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian
Patent: WO2011/38204 A1, 2011 ;
Location in patent: Page/Page column 139 ;
WO 2011/038204 A1
反应条件
in tetrahydrofuran
T=-78°C; 3 h;
参考文献
ALLERGAN, INC.
Patent: US2007/270498 A1, 2007 ;
Location in patent: Page/Page column 10 ;
反应条件
1: 2-chloro-benzyl chloride With magnesium in diethyl ether
T=20°C; Grignard reaction;
2: benzonitrile in tetrahydrofuran; diethyl ether
0.5 h; Heating; Further stages.;
参考文献
Ceder; Muller; Ordinas; Maestro; Mahia; Bardia; Solans
Journal of the Chemical Society, Dalton Transactions, 2001 , # 7 p. 977 - 985
反应条件
bis-triphenylphosphine-palladium(II) chloride; triethylamine in tetrahydrofuran
T=80°C; 3 h; Schlenk tubeInert atmosphere;
参考文献
Rao, Maddali L.N.; Giri, Somnath; Jadhav, Deepak N.
Tetrahedron Letters, 2009 , vol. 50, # 45 p. 6133 - 6138
反应条件
1: 2-chloro-benzyl chloride With indium(III) chloride; manganese; chloro-trimethyl-silane; palladium dichloride in tetrahydrofuran
T=25°C; 16 h; Inert atmosphere;
2: benzoyl chloride in tetrahydrofuran
T=0 - 25°C; Inert atmosphere;
参考文献
Peng, Zhihua; Knochel, Paul
Organic Letters, 2011 , vol. 13, # 12 p. 3198 - 3201
反应条件
1: With titanium tetrachloride; tert-butylamine in toluene
T=120°C; 22 h;
2: With hydrogenchloride in toluene
T=20°C; Further stages. Title compound not separated from byproducts.;
参考文献
Ackermann, Lutz; Kaspar, Ludwig T.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6149 - 6153
反应条件
aluminium trichloride
参考文献
Shapiro; Becker
Journal of the American Chemical Society, 1953 , vol. 75, p. 4769,4771
反应条件
diethyl ether; hydrogen
Behandeln des Reaktionsgemisches mit Eis und Schwefelsaeure;
参考文献
Jenkins; Richardson
Journal of the American Chemical Society, 1933 , vol. 55, p. 1618,1619
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 2 h / 20 °C / Inert atmosphere
2: tetrahydrofuran / 5 h / -78 °C / Inert atmosphere
View Scheme
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian
Patent: WO2011/38204 A1, 2011 ;
WO 2011/038204 A1
