2-(2-溴苯基)乙酸甲酯合成路线 （共 28 条）
反应条件
hydrogenchloride 2.5 h; Heating;
参考文献
Kapadia, Nirav; Harding, Wayne
Tetrahedron, 2013 , vol. 69, # 42 p. 8914 - 8920
反应条件
in methanol; toluene T=20°C; 0.0833333 h;
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA
Patent: EP1894911 A1, 2008 ;
Location in patent: Page/Page column 177-178 ;
反应条件
hydrogenchloride in tetrahydrofuran; water
反应条件
1: 2-(2-bromophenyl)acetic acid With potassium carbonate in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
in dichloromethane T=20°C; Inert atmosphere;
参考文献
ELI LILLY AND COMPANY; HIPSKIND, Philip Arthur; STEPHENSON, Gregory Alan
Patent: US2013/29972 A1, 2013 ;
Location in patent: Paragraph 0031-0032 ;
US 20130029972 A1
反应条件
sodium peroxodisulphate; N-bromosuccinmide; trifluorormethanesulfonic acid; palladium diacetate in 1,2-dichloro-ethane T=60°C; 1.5 h; Sealed tube; regioselective reaction;
参考文献
Sun, Xiuyun; Shan, Gang; Sun, Yonghui; Rao, Yu
Angewandte Chemie - International Edition, 2013 , vol. 52, # 16 p. 4440 - 4444
Angew. Chem., 2013 , vol. 125, # 16 p. 4536 - 4540,5
参考文献
US6048893 A1, ;
US 6048893 A
US6124343 A1, ;
反应条件
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 5.12 h / 20 °C 2: dichloromethane / 20 °C / |Inert atmosphere View Scheme
参考文献
US2013/29972 A1, ;
US 20130029972 A1
反应条件
1.1: caesium carbonate / copper(l) chloride; glycine / 1,4-dioxane / 120 h / Reflux 1.2: pH 1 2.1: thionyl chloride / toluene / 1 h / 50 °C 3.1: triethylamine / N,N-dimethyl-formamide; toluene / 2.17 h / 5 - 20 °C View Scheme
参考文献
Medichem, S.A.
Patent: EP2468751 A2, 2012 ;
反应条件
1: dimethylformamide / Heating 2: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 3: Et3N / tetrahydrofuran / 25 °C 4: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
