2-(2-溴苯基)乙酸甲酯合成路线 （共 28 条）
反应条件
1: dimethylformamide / Heating 2: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 3: Et3N / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: With caesium carbonate; glycine; copper(l) chloride in 1,4-dioxane 120 h; Reflux; 2: With hydrogenchloride in water; ethyl acetate pH=1;
参考文献
Medichem, S.A.
Patent: EP2468751 A2, 2012 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: With tetrakis(triphenylphosphine) palladium(0); caesium carbonate in ethylene glycol dimethyl ether T=125°C; 0.5 h; Microwave irradiationInert atmosphereSealed tube; 2: With potassium tert-butylate in tetrahydrofuran; ethylene glycol dimethyl ether T=0 - 20°C; 0.166667 h; Inert atmosphereSealed tube; Reagent/catalystSolvent;
参考文献
Deb, Prasant K.; Sharma, Somesh; Borude, Avinash; Singh, Ravi P.; Kumar, Deepak; Reddy, L. Krishnakanth
Tetrahedron Letters, 2013 , vol. 54, # 23 p. 2916 - 2919
反应条件
1: 1.) LDA / 1.) THF, hexane, -75 deg C, 30 min, 2.) THF, hexane, a) -75 deg C, 90 min, b) RT, 90 min 2: 85 percent / LiAlH4 / diethyl ether / 2 h / Ambient temperature 3: 0.25 h / Ambient temperature 4: LiI, hexamethylphosphoric triamide (HMPA) / tetrahydrofuran / 6 h / Heating 5: 54 percent / trimethoxyborohydride, hexamethylphosphoric triamide / 3 h / Ambient temperature View Scheme
参考文献
Beckwith, Athelstan L. J.; Gerba, Sendaba
Australian Journal of Chemistry, 1992 , vol. 45, # 1 p. 289 - 308
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C 1.2: 18 h / 20 °C 2.1: sodium hydroxide / ethanol; water / 1 h / Reflux 2.2: pH 2 View Scheme
参考文献
Kukosha, Tatyana; Trufilkina, Nadezhda; Katkevics, Martins
Synlett, 2011 , # 17 p. 2525 - 2528
反应条件
sodium tetrahydroborate; calcium chloride in ethanol T=0 - 20°C; 16 h; Inert atmosphere;
参考文献
Kapadia, Nirav; Harding, Wayne
Tetrahedron, 2013 , vol. 69, # 42 p. 8914 - 8920
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 4 h;
参考文献
Bonaventure, Pascal; Carruthers, Nicholas I.; Chai, Wenying; Dvorak, Curt A.; Jablonowski, Jill A.; Rudolph, Dale A.; Seierstad, Mark; Shah, Chandravadan R.; Swanson, Devin M.; Wong, Victoria D.
Patent: US2007/100141 A1, 2007 ;
Location in patent: Page/Page column 50 ;
US 20070100141 A1
反应条件
1: 1.) LDA / 1.) THF, hexane, -75 deg C, 30 min, 2.) THF, hexane, a) -75 deg C, 90 min, b) RT, 90 min 2: 1.) LDA / 1.) THF, hexane, -75 deg C, 30 min, 2.) THF, hexane, a) -75 deg C, 90 min, b) RT, 90 min View Scheme
参考文献
Beckwith, Athelstan L. J.; Gerba, Sendaba
Australian Journal of Chemistry, 1992 , vol. 45, # 1 p. 289 - 308
反应条件
1.1: DIBAL / toluene / 2 h / -78 °C 1.2: methanol; toluene / 1.5 h / -78 - 20 °C 2.1: 73 percent / tetrahydrofuran; diethyl ether / 1.5 h / -20 - 20 °C 3.1: 59 percent / (1,2,3,4,5-pentaphenylferrocen-1'-yl)-di-tert-butylphosphine; bis(dibenzylideneacetone) palladium(0); sodium tert-butoxide / toluene / 5 h / 20 °C View Scheme
参考文献
Kataoka, Noriyasu; Shelby, Quinetta; Stambuli, James P.; Hartwig, John F.
Journal of Organic Chemistry, 2002 , vol. 67, # 16 p. 5553 - 5566
反应条件
1: in water; N,N-dimethyl-formamide T=20°C; Heating / reflux; 2: With anhydrous iron chloride
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher William; Dolle, Roland E.
Patent: US2004/254156 A1, 2004 ;
Location in patent: Page 16 ;
