2-(2-溴苯基)乙酸甲酯合成路线 （共 28 条）
反应条件
in N,N-dimethyl-formamide Heating;
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: 64 percent / K2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 18 h / Heating
2: KOH / H2O / 0.5 h / Heating
View Scheme
参考文献
Suau; Rico; Najera; Ortiz-Lopez; Lopez-Romero; Moreno-Manas; Roglans
Tetrahedron, 2004 , vol. 60, # 27 p. 5725 - 5735
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethylene glycol dimethyl ether; water / 0.08 h
1.2: 12 h / 100 °C
2.1: 4-Acetylaminobenzenesulfonyl Azide / tetrahydrofuran / 0.08 h / Inert atmosphere
2.2: 12 h / 25 °C / Inert atmosphere
3.1: dirhodium tetraacetate / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Kim, Jinho; Ohk, Youhwa; Park, Sae Hume; Jung, Yousung; Chang, Sukbok
Chemistry - An Asian Journal, 2011 , vol. 6, # 8 p. 2040 - 2047
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane
T=20°C; Inert atmosphereReflux;
参考文献
Yougnia, Rodrigue; Rochais, Christophe; Oliveira Santos, Jana Sopkova-de; Dallemagne, Patrick; Rault, Sylvain
Tetrahedron, 2010 , vol. 66, # 15 p. 2803 - 2808
反应条件
1: With diisobutylaluminium hydride in toluene
T=-78°C; 2 h;
2: in methanol; toluene
T=-78 - 20°C; 1.5 h; Further stages.;
参考文献
Kapadia, Nirav; Harding, Wayne
Tetrahedron, 2013 , vol. 69, # 42 p. 8914 - 8920
反应条件
caesium carbonate; N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine; tetrakis(triphenylphosphine) palladium(0) in ethanol; toluene
T=120 - 150°C; 0.166667 h; microwave irradiation;
参考文献
Young, Ha Kim; Lee, Hyuk; Yeong, Joon Kim; Bum, Tae Kim; Heo, Jung-Nyoung
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 495 - 501
反应条件
1: 89 percent / CsF / Pd(PPh3)4 / 1,2-dimethoxy-ethane / 5 h / Heating
2: 100 percent / LAH / tetrahydrofuran / 3 h / Ambient temperature
3: 81 percent / PCC / CH2Cl2 / 3 h / Ambient temperature
4: 73 percent / Me3SO3H / CHCl3 / 2 h / Ambient temperature
View Scheme
参考文献
Kumar, Subodh
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 19 p. 3157 - 3161
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethylene glycol dimethyl ether; water / 0.08 h
1.2: 12 h / 100 °C
2.1: 4-Acetylaminobenzenesulfonyl Azide / tetrahydrofuran / 0.08 h / Inert atmosphere
2.2: 12 h / 25 °C / Inert atmosphere
3.1: dirhodium tetraacetate / 1,2-dichloro-ethane / 1 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Kim, Jinho; Ohk, Youhwa; Park, Sae Hume; Jung, Yousung; Chang, Sukbok
Chemistry - An Asian Journal, 2011 , vol. 6, # 8 p. 2040 - 2047
