4-(4-甲基苯基)-4-氧代丁酸甲酯合成路线 （共 18 条）
反应条件
sulfuric acid T=20°C; 12 h;
参考文献
The Research Foundation of State University of New York
Patent: US7700798 B1, 2010 ;
Location in patent: Page/Page column 28 ;
反应条件
3-methyl-2-amino-pyridine; benzoic acid; Wilkinson's catalyst in toluene T=130°C; 1 h;
参考文献
Jo, Eun-Ae; Jun, Chul-Ho
European Journal of Organic Chemistry, 2006 , # 11 p. 2504 - 2507
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 3 h;
参考文献
WO2004/45616 A1, ;
Page/Page column 34-35 ;
反应条件
p-toluenesulfonic acid monohydrate in methanol; ethyl acetate
反应条件
copper(I) bromide; lithium bromide in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Babudri, Francesco; Fiandanese, Vito; Marchese, Giuseppe; Punzi, Angela
Tetrahedron, 1996 , vol. 52, # 42 p. 13513 - 13520
反应条件
1: 82 percent / pTSA / toluene 2: RhCl(PPh3)3 / tetrahydrofuran / 6 h / 135 °C 3: aq. HCl / tetrahydrofuran; ethyl acetate / 20 °C View Scheme
参考文献
Chemical Communications, , # 24 p. 2558 - 2559
反应条件
Cu(thd)2 in acetonitrile 24 h; Ambient temperature;
参考文献
Sakurai, Hidehiro; Narasaka, Koichi
Chemistry Letters, 1994 , # 11 p. 2017 - 2020
反应条件
potassium carbonate in acetone esterification; Heating;
参考文献
Khan; Siddiqui
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 8 p. 614 - 619
反应条件
sodium tetrahydroborate; sodium hydrogencarbonate in methanol; water T=28°C; 1.5 h;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 20, # 5 p. 355 - 358
反应条件
1: 76 percent / AlCl3 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 11 p. 3546 - 3552
