4-(4-甲基苯基)-4-氧代丁酸甲酯合成路线 （共 18 条）
反应条件
Friedel-Crafts conditions;
参考文献
Journal of the American Chemical Society, , vol. 103, # 11 p. 3219 - 3220
参考文献
Journal of Organic Chemistry, , vol. 15, p. 785,787
反应条件
sodium acetate; hydrazine hydrate in methanol condensation; Heating;
参考文献
Khan; Siddiqui
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 8 p. 614 - 619
参考文献
Bhat, K. S.; Rao, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 5 p. 355 - 358
反应条件
sodium acetate in methanol condensation; Heating;
参考文献
Khan; Siddiqui
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 8 p. 614 - 619
反应条件
1: 100 percent / bromine / AlCl3 / diethyl ether; CCl4 / 0.08 h 2: 31 percent / NaBH4, NaHCO3 / methanol; H2O / 1.5 h / 28 °C 3: 2.) NaOH / 1.) 195-200 deg C , 45 min , 2.) H2O , EtOH , heating , 1 h View Scheme
参考文献
Bhat, K. S.; Rao, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 5 p. 355 - 358
反应条件
1: 100 percent / bromine / AlCl3 / diethyl ether; CCl4 / 0.08 h
2: 31 percent / NaBH4, NaHCO3 / methanol; H2O / 1.5 h / 28 °C
3: 95 percent / BF3*OEt2 / benzene / 1.5 h / Ambient temperature
View Scheme
参考文献
Bhat, K. S.; Rao, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 5 p. 355 - 358
反应条件
toluene-4-sulfonic acid
Heating;
参考文献
Taylor, Edward C.; Conley, Richard A.; Katz, Alan H; McKillop, Alexander
Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3840 - 3841
